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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-9-27
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pubmed:abstractText |
The present study was designed to determine the role of endogenous brain interleukin (IL)-1 in the anorexic response to lipopolysaccharide (LPS). Intraperitoneal administration of LPS (5-10 microgram/mouse) induced a dramatic, but transient, decrease in food intake, associated with an enhanced expression of proinflammatory cytokine mRNA (IL-1beta, IL-6, and tumor necrosis factor-alpha) in the hypothalamus. This dose of LPS also increased plasma levels of IL-1beta. Intracerebroventricular pretreatment with IL-1 receptor antagonist (4 microgram/mouse) attenuated LPS-induced depression of food intake and totally blocked the LPS-induced enhanced expression of proinflammatory cytokine mRNA measured in the hypothalamus 1 h after treatment. In contrast, LPS-induced increases in plasma levels of IL-1beta were not altered. These findings indicate that endogenous brain IL-1 plays a pivotal role in the development of the hypothalamic cytokine response to a systemic inflammatory stimulus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Il1rn protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin 1 Receptor Antagonist...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0363-6119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
279
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R93-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10896869-Analysis of Variance,
pubmed-meshheading:10896869-Animals,
pubmed-meshheading:10896869-Anorexia,
pubmed-meshheading:10896869-Catheterization,
pubmed-meshheading:10896869-Cytokines,
pubmed-meshheading:10896869-Eating,
pubmed-meshheading:10896869-Hypothalamus,
pubmed-meshheading:10896869-Injections, Intraperitoneal,
pubmed-meshheading:10896869-Injections, Intraventricular,
pubmed-meshheading:10896869-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:10896869-Interleukin-1,
pubmed-meshheading:10896869-Interleukin-6,
pubmed-meshheading:10896869-Lipopolysaccharides,
pubmed-meshheading:10896869-Male,
pubmed-meshheading:10896869-Mice,
pubmed-meshheading:10896869-Mice, Inbred ICR,
pubmed-meshheading:10896869-RNA, Messenger,
pubmed-meshheading:10896869-Receptors, Interleukin-1,
pubmed-meshheading:10896869-Sialoglycoproteins,
pubmed-meshheading:10896869-Tumor Necrosis Factor-alpha
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pubmed:year |
2000
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pubmed:articleTitle |
Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression.
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pubmed:affiliation |
Institut National de la Recherche Agronomique-Institut National de la Santé et de la Recherche Médicale Unité 394, Neurobiologie Intégrative, 33077 Bordeaux, France. s.laye@neurocyto.ubordeaux.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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