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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-9-27
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pubmed:abstractText |
Overexpression of agouti-related peptide (AgRP), an endogenous melanocortin (MC) 3 and 4 receptor antagonist (MC3/4-R), causes obesity. Exogenous AgRP-(83---132) increases food intake, but its duration and mode of action are unknown. We report herein that doses as low as 10 pmol can have a potent effect on food intake of rats over a 24-h period after intracerebroventricular injection. Additionally, a single third ventricular dose as low as 100 pmol in rats produces a robust increase in food intake that persists for an entire week. AgRP-(83---132) completely blocks the anorectic effect of MTII (MC3/4-R agonist), given simultaneously, consistent with a competitive antagonist action. However, when given 24 h prior to MTII, AgRP-(83---132) is ineffective at reversing the anorectic effects of the agonist. These results support a critical role of MC tone in limiting food intake and indicate that the orexigenic effects of AgRP-(83---132) are initially mediated by competitive antagonism at MC receptors but are sustained by alternate mechanisms.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Agouti-Related Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Appetite Stimulants,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Melanocortin, Type 3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Melanocortin, Type 4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Corticotropin,
http://linkedlifedata.com/resource/pubmed/chemical/acetyl-norleucyl(4)-(aspartyl(5)-his...,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-MSH
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0363-6119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
279
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R47-52
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10896863-Agouti-Related Protein,
pubmed-meshheading:10896863-Animals,
pubmed-meshheading:10896863-Appetite Stimulants,
pubmed-meshheading:10896863-Body Weight,
pubmed-meshheading:10896863-Dose-Response Relationship, Drug,
pubmed-meshheading:10896863-Eating,
pubmed-meshheading:10896863-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:10896863-Oligopeptides,
pubmed-meshheading:10896863-Peptide Fragments,
pubmed-meshheading:10896863-Proteins,
pubmed-meshheading:10896863-Rats,
pubmed-meshheading:10896863-Rats, Long-Evans,
pubmed-meshheading:10896863-Receptor, Melanocortin, Type 3,
pubmed-meshheading:10896863-Receptor, Melanocortin, Type 4,
pubmed-meshheading:10896863-Receptors, Corticotropin,
pubmed-meshheading:10896863-Time,
pubmed-meshheading:10896863-alpha-MSH
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pubmed:year |
2000
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pubmed:articleTitle |
Long-term orexigenic effects of AgRP-(83---132) involve mechanisms other than melanocortin receptor blockade.
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pubmed:affiliation |
Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0559, USA. haganmm@email.uc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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