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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-8-7
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pubmed:databankReference |
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pubmed:abstractText |
Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a substrate of the c-Abl tyrosine kinase. Active c-Abl kinase leads to Cdk5 tyrosine phosphorylation, and this phosphorylation is enhanced by Cables. Phosphorylation of Cdk5 by c-Abl occurs on tyrosine 15 (Y15), which is stimulatory for p35/Cdk5 kinase activity. Expression of antisense Cables in primary cortical neurons inhibited neurite outgrowth. Furthermore, expression of active Abl resulted in lengthening of neurites. The data provide evidence for a Cables-mediated interplay between the Cdk5 and c-Abl signaling pathways in the developing nervous system.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cables1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cdk5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 5,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-abl,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
633-46
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10896159-Amino Acid Sequence,
pubmed-meshheading:10896159-Animals,
pubmed-meshheading:10896159-Base Sequence,
pubmed-meshheading:10896159-COS Cells,
pubmed-meshheading:10896159-Carrier Proteins,
pubmed-meshheading:10896159-Cells, Cultured,
pubmed-meshheading:10896159-Cyclin-Dependent Kinase 5,
pubmed-meshheading:10896159-Cyclin-Dependent Kinases,
pubmed-meshheading:10896159-Cyclins,
pubmed-meshheading:10896159-Embryo, Mammalian,
pubmed-meshheading:10896159-Mice,
pubmed-meshheading:10896159-Mitosis,
pubmed-meshheading:10896159-Molecular Sequence Data,
pubmed-meshheading:10896159-Neurites,
pubmed-meshheading:10896159-Neurons,
pubmed-meshheading:10896159-Phosphoproteins,
pubmed-meshheading:10896159-Phosphorylation,
pubmed-meshheading:10896159-Phosphotransferases,
pubmed-meshheading:10896159-Proto-Oncogene Proteins c-abl,
pubmed-meshheading:10896159-Substrate Specificity,
pubmed-meshheading:10896159-Tyrosine,
pubmed-meshheading:10896159-Up-Regulation
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pubmed:year |
2000
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pubmed:articleTitle |
Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Pathology, Massachusetts General Hospital, Boston 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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