Linked Life Data

10895694

Source:http://linkedlifedata.com/resource/pubmed/id/10895694

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-7-20
pubmed:abstractText
Pathogen-related oral spirochetes were identified in dental plaque using monoclonal antibodies to putative Treponema pallidum-specific proteins, and serum from subjects with necrotizing ulcerative gingivitis contained immunoglobulin G to molecules thought to be restricted to T. pallidum. The purpose of this study was to determine whether subjects with periodontitis were more likely to have serum antibodies to T. pallidum if pathogen-related oral spirochetes were present. Pathogen-related oral spirochetes were detected in subgingival plaque from 27 of 40 subjects, and 33 subjects had serum antibodies that bound T. pallidum proteins in immunoblots. Subjects with pathogen-related oral spirochetes were no more likely to have IgA, IgG or IgM to 15-, 37- or 47-kDa proteins than were subjects without pathogen-related oral spirochetes. In contrast to subjects with necrotizing ulcerative gingivitis, subjects with periodontitis had no detectable antibodies to 37- or 12-kDa proteins. Further research is needed to identify the stimulus for antibodies that cross-react with T. pallidum proteins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0902-0055
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
375-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Antibodies to Treponema pallidum in serum from subjects with periodontitis: relationship to pathogen-related oral spirochetes.
pubmed:affiliation
Department of Pediatric Dentistry, School of Dentistry, Oregon Health Sciences University, Portland 97201-3097, USA.
pubmed:publicationType
Journal Article, Comparative Study