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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5477
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pubmed:dateCreated |
2000-7-25
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pubmed:abstractText |
Bone morphogenetic proteins (BMPs) have multiple functions in the developing nervous system. A member of this family, BMP-9, was found to be highly expressed in the embryonic mouse septum and spinal cord, indicating a possible role in regulating the cholinergic phenotype. In cultured neurons, BMP-9 directly induced the expression of the cholinergic gene locus encoding choline acetyltransferase and the vesicular acetylcholine transporter and up-regulated acetylcholine synthesis. The effect was reversed upon withdrawal of BMP-9. Intracerebroventricular injection of BMP-9 increased acetylcholine levels in vivo. Although certain other BMPs also up-regulated the cholinergic phenotype in vitro, they were less effective than BMP-9. These data indicate that BMP-9 is a differentiating factor for cholinergic central nervous system neurons.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Choline O-Acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Differentiation Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Slc18a3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Acetylcholine Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Transport Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
289
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
313-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10894782-Acetylcholine,
pubmed-meshheading:10894782-Animals,
pubmed-meshheading:10894782-Bone Morphogenetic Proteins,
pubmed-meshheading:10894782-Carrier Proteins,
pubmed-meshheading:10894782-Cells, Cultured,
pubmed-meshheading:10894782-Central Nervous System,
pubmed-meshheading:10894782-Choline O-Acetyltransferase,
pubmed-meshheading:10894782-Embryo, Mammalian,
pubmed-meshheading:10894782-Fibroblast Growth Factor 2,
pubmed-meshheading:10894782-Gene Expression Regulation, Developmental,
pubmed-meshheading:10894782-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:10894782-Growth Differentiation Factor 2,
pubmed-meshheading:10894782-Membrane Transport Proteins,
pubmed-meshheading:10894782-Mice,
pubmed-meshheading:10894782-Neurons,
pubmed-meshheading:10894782-Phenotype,
pubmed-meshheading:10894782-RNA, Messenger,
pubmed-meshheading:10894782-Septum of Brain,
pubmed-meshheading:10894782-Spinal Cord,
pubmed-meshheading:10894782-Up-Regulation,
pubmed-meshheading:10894782-Vesicular Acetylcholine Transport Proteins,
pubmed-meshheading:10894782-Vesicular Transport Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9.
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pubmed:affiliation |
Department of Psychiatry and Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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