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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2000-7-31
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pubmed:abstractText |
Casper (c-FLIP) associates with FADD and caspase-8 in signaling complexes downstream of death receptors like Fas. We generated Casper-deficient mice and cells and noted a duality in the physiological functions of this molecule. casper-/- embryos do not survive past day 10.5 of embryogenesis and exhibit impaired heart development. This phenotype is reminiscent of that reported for FADD-/- and caspase-8-/- embryos. However, unlike FADD-/- and caspase-8-/- cells, casper-/- embryonic fibroblasts are highly sensitive to FasL- or TNF-induced apoptosis and show rapid induction of caspase activities. NF-kappaB and JNK/SAPK activation is intact in TNF-stimulated casper-/- cells. These results suggest that Casper has two distinct roles: to cooperate with FADD and caspase-8 during embryonic development and to mediate cytoprotection against death factor-induced apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 and FADD-Like Apoptosis...,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Casp8 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Casp9 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cflar protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1074-7613
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pubmed:author |
pubmed-author:BonnardMM,
pubmed-author:EliaA JAJ,
pubmed-author:GoeddelD VDV,
pubmed-author:ItieAA,
pubmed-author:MaoT STS,
pubmed-author:MirtsosCC,
pubmed-author:OINN,
pubmed-author:SitH LHL,
pubmed-author:SuzukiNN,
pubmed-author:WakehamAA,
pubmed-author:YeeW HWH
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
633-42
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10894163-Animals,
pubmed-meshheading:10894163-Apoptosis,
pubmed-meshheading:10894163-CASP8 and FADD-Like Apoptosis Regulating Protein,
pubmed-meshheading:10894163-Carrier Proteins,
pubmed-meshheading:10894163-Caspase 3,
pubmed-meshheading:10894163-Caspase 8,
pubmed-meshheading:10894163-Caspase 9,
pubmed-meshheading:10894163-Caspases,
pubmed-meshheading:10894163-Cell Line,
pubmed-meshheading:10894163-Embryonic and Fetal Development,
pubmed-meshheading:10894163-Enzyme Activation,
pubmed-meshheading:10894163-Female,
pubmed-meshheading:10894163-Heart,
pubmed-meshheading:10894163-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:10894163-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:10894163-Male,
pubmed-meshheading:10894163-Mice,
pubmed-meshheading:10894163-Mice, Inbred C57BL,
pubmed-meshheading:10894163-Mice, Knockout,
pubmed-meshheading:10894163-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10894163-Myocardium,
pubmed-meshheading:10894163-NF-kappa B,
pubmed-meshheading:10894163-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:10894163-Stem Cells,
pubmed-meshheading:10894163-Tumor Necrosis Factor-alpha
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pubmed:year |
2000
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pubmed:articleTitle |
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.
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pubmed:affiliation |
Amgen Institute, Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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