|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0023789,
umls-concept:C0035339,
umls-concept:C0086418,
umls-concept:C0449432,
umls-concept:C0674444,
umls-concept:C1179435,
umls-concept:C1419621,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2000-7-31
|
|
pubmed:abstractText |
A fluorescent component of lipofuscin, A2-E (N-retinylidene-N-retinylethanol-amine) has been shown to impair lysosomal function and to increase the intralysosomal pH of human retinal pigment epithelial (RPE) cells. In addition to its lysosomotropic properties A2-E is known to be photoreactive. The purpose of this study was to determine the phototoxic potential of A2-E on RPE cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0146-0404
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
41
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2303-8
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10892877-Acridine Orange,
pubmed-meshheading:10892877-Cell Survival,
pubmed-meshheading:10892877-Cells, Cultured,
pubmed-meshheading:10892877-Flow Cytometry,
pubmed-meshheading:10892877-Fluorescent Dyes,
pubmed-meshheading:10892877-Humans,
pubmed-meshheading:10892877-Light,
pubmed-meshheading:10892877-Lipofuscin,
pubmed-meshheading:10892877-Lysosomes,
pubmed-meshheading:10892877-Microscopy, Fluorescence,
pubmed-meshheading:10892877-Pigment Epithelium of Eye,
pubmed-meshheading:10892877-Retinal Pigments,
pubmed-meshheading:10892877-Retinoids
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin.
|
|
pubmed:affiliation |
Department of Ophthalmology, University of Heidelberg, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
