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rdf:type |
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lifeskim:mentions |
umls-concept:C0023317,
umls-concept:C0026336,
umls-concept:C0033684,
umls-concept:C0042666,
umls-concept:C0086418,
umls-concept:C0205263,
umls-concept:C0271160,
umls-concept:C0449584,
umls-concept:C0596235,
umls-concept:C0596311,
umls-concept:C1330957,
umls-concept:C1517945
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pubmed:issue |
8
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pubmed:dateCreated |
2000-7-31
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pubmed:abstractText |
Cortical cataract in humans is associated with Ca2+ overload and protein loss, and although animal models of cataract have implicated Ca2+-activated proteases in this process, it remains to be determined whether the human lens responds in this manner to conditions of Ca2+ overload. The purpose of these experiments was to investigate Ca2+-induced opacification and proteolysis in the organ-cultured human lens.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2255-61
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10892870-Adolescent,
pubmed-meshheading:10892870-Adult,
pubmed-meshheading:10892870-Aged,
pubmed-meshheading:10892870-Aged, 80 and over,
pubmed-meshheading:10892870-Blotting, Western,
pubmed-meshheading:10892870-Calcium,
pubmed-meshheading:10892870-Cataract,
pubmed-meshheading:10892870-Crystallins,
pubmed-meshheading:10892870-Culture Media,
pubmed-meshheading:10892870-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:10892870-Humans,
pubmed-meshheading:10892870-Ionomycin,
pubmed-meshheading:10892870-Ionophores,
pubmed-meshheading:10892870-Lens Cortex, Crystalline,
pubmed-meshheading:10892870-Luminescent Measurements,
pubmed-meshheading:10892870-Middle Aged,
pubmed-meshheading:10892870-Models, Biological,
pubmed-meshheading:10892870-Organ Culture Techniques,
pubmed-meshheading:10892870-Vimentin
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pubmed:year |
2000
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pubmed:articleTitle |
A human lens model of cortical cataract: Ca2+-induced protein loss, vimentin cleavage and opacification.
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pubmed:affiliation |
School of Biological Sciences, University of East Anglia, Norwich, United Kingdom. j.sanderson@uea.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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