| pubmed-article:10890359 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10890359 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:10890359 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:10890359 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:10890359 | lifeskim:mentions | umls-concept:C1622204 | lld:lifeskim |
| pubmed-article:10890359 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:10890359 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:10890359 | lifeskim:mentions | umls-concept:C0043476 | lld:lifeskim |
| pubmed-article:10890359 | lifeskim:mentions | umls-concept:C0332185 | lld:lifeskim |
| pubmed-article:10890359 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:10890359 | pubmed:dateCreated | 2000-11-15 | lld:pubmed |
| pubmed-article:10890359 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10890359 | pubmed:abstractText | HIV-1 envelope sequence patterns have implications for virus cell tropism and for the development of an effective vaccine. To identify the sequence characteristics of recently transmitted HIV-1 isolates in southern Africa, we sequenced the V3-V5 envelope regions of 24 male seroconverters in Harare, Zimbabwe. Each of the sequences clustered with previously reported subtype C isolates and there was a mean 17% intersequence pairwise genetic distance between the Zimbabwean isolates. Three isolates were syncytium inducing (SI). One of the SI isolates had an unusual GIGK crown and a deletion at codon 23; one had the codon 23 deletion alone; and one had a high net positive charge in the V3 loop. The extensive genetic diversity within the envelope of subtype C HIV-1 isolates must be considered in vaccine development. Further analysis of subtype C SI isolates and site-directed mutagenesis experiments are required to determine the molecular basis of SI activity in global HIV-1 isolates. | lld:pubmed |
| pubmed-article:10890359 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10890359 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10890359 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10890359 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10890359 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10890359 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10890359 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10890359 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10890359 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10890359 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10890359 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10890359 | pubmed:issn | 0889-2229 | lld:pubmed |
| pubmed-article:10890359 | pubmed:author | pubmed-author:RouxMM | lld:pubmed |
| pubmed-article:10890359 | pubmed:author | pubmed-author:ShaferR WRW | lld:pubmed |
| pubmed-article:10890359 | pubmed:author | pubmed-author:BatraMM | lld:pubmed |
| pubmed-article:10890359 | pubmed:author | pubmed-author:KatzensteinD... | lld:pubmed |
| pubmed-article:10890359 | pubmed:author | pubmed-author:ContagC HCH | lld:pubmed |
| pubmed-article:10890359 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10890359 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10890359 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:10890359 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10890359 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10890359 | pubmed:pagination | 973-9 | lld:pubmed |
| pubmed-article:10890359 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10890359 | pubmed:meshHeading | pubmed-meshheading:10890359... | lld:pubmed |
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| pubmed-article:10890359 | pubmed:meshHeading | pubmed-meshheading:10890359... | lld:pubmed |
| pubmed-article:10890359 | pubmed:meshHeading | pubmed-meshheading:10890359... | lld:pubmed |
| pubmed-article:10890359 | pubmed:meshHeading | pubmed-meshheading:10890359... | lld:pubmed |
| pubmed-article:10890359 | pubmed:meshHeading | pubmed-meshheading:10890359... | lld:pubmed |
| pubmed-article:10890359 | pubmed:meshHeading | pubmed-meshheading:10890359... | lld:pubmed |
| pubmed-article:10890359 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10890359 | pubmed:articleTitle | HIV type 1 envelope subtype C sequences from recent seroconverters in Zimbabwe. | lld:pubmed |
| pubmed-article:10890359 | pubmed:affiliation | Center for AIDS Research, Stanford University School of Medicine, California 94305, USA. | lld:pubmed |
| pubmed-article:10890359 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10890359 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10890359 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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