Source:http://linkedlifedata.com/resource/pubmed/id/10889454
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2000-11-7
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| pubmed:abstractText |
A large body of experimental research indicates that oxidative stress contributes to the processes related to aging and to the pathogenesis of several age-related diseases. Vitamins and antioxidant enzymes have a fundamental role in defending the organism from oxidative stress. To better understand the role of antioxidants in human aging, we measured plasma levels of vitamin C (ascorbic acid), uric acid, vitamin E (alpha-tocopherol), vitamin A (retinol), carotenoids, total thiol groups, and the activity of plasma superoxide dismutase (SOD) and glutathione peroxidase (GPX) as well as the activity of red blood cell (RBC) SOD in 32 healthy centenarians-17 elderly subjects aged 80-99 years, 34 elderly subjects aged 60-79 years, and 24 adults aged less than 60 years. Considering the "noncentenarians" only, we observed a consistent behavior in the antioxidant pattern, with a decrease of the nonenzymatic antioxidants and an increase of the enzymatic antioxidant activities relative to age. Remarkably, centenarians were characterized as having the highest levels of vitamins A and E, whereas the activities of both plasma and RBC SOD, which increase with age, decreased in centenarians. From these results, it is evident that healthy centenarians show a particular profile in which high levels of vitamin A and vitamin E seem to be important in guaranteeing their extreme longevity.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Ascorbic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Carotenoids,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfhydryl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Uric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin A,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamins
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0891-5849
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1243-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10889454-Aged,
pubmed-meshheading:10889454-Aged, 80 and over,
pubmed-meshheading:10889454-Aging,
pubmed-meshheading:10889454-Antioxidants,
pubmed-meshheading:10889454-Ascorbic Acid,
pubmed-meshheading:10889454-Carotenoids,
pubmed-meshheading:10889454-Erythrocytes,
pubmed-meshheading:10889454-Female,
pubmed-meshheading:10889454-Glutathione Peroxidase,
pubmed-meshheading:10889454-Humans,
pubmed-meshheading:10889454-Longevity,
pubmed-meshheading:10889454-Male,
pubmed-meshheading:10889454-Middle Aged,
pubmed-meshheading:10889454-Oxidative Stress,
pubmed-meshheading:10889454-Sulfhydryl Compounds,
pubmed-meshheading:10889454-Superoxide Dismutase,
pubmed-meshheading:10889454-Uric Acid,
pubmed-meshheading:10889454-Vitamin A,
pubmed-meshheading:10889454-Vitamin E,
pubmed-meshheading:10889454-Vitamins
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| pubmed:year |
2000
|
| pubmed:articleTitle |
Plasma antioxidants and longevity: a study on healthy centenarians.
|
| pubmed:affiliation |
Sezione di Gerontologia e Geriatria, Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Perugia, Italy. geriat@unipg.it
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|