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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2000-9-5
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pubmed:abstractText |
Two strains of mice (NMRI and C57/BL) were each immunized with a 15kDa recombinant Fasciola hepatica fatty acid binding protein (FABP) (Fh15) and challenged percutaneously with Schistosoma bovis cercariae. C57/BL mice immunized with Fh15 had significant reductions in S. bovis worm burden recoveries (72% reductions over controls). When using NMRI mice, Fh15 in Freund's adjuvant failed to induce significant protection against S. bovis. In C57/BL mice, only antibodies to the IgG2a isotype increased after the second immunization and remained high through 8 weeks of S. bovis infection. This is the first time that a heterologous recombinant molecule from F. hepatica has been used in vaccination against S. bovis, obtaining a significant reduction in the number of worms in C57/BL mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Helminth,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fabp5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fabp7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fh15 protein, Fasciola hepatica,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin P2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0304-4017
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-42
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10889358-Animals,
pubmed-meshheading:10889358-Antibodies, Helminth,
pubmed-meshheading:10889358-Carrier Proteins,
pubmed-meshheading:10889358-Fasciola hepatica,
pubmed-meshheading:10889358-Fatty Acid-Binding Proteins,
pubmed-meshheading:10889358-Helminth Proteins,
pubmed-meshheading:10889358-Liver,
pubmed-meshheading:10889358-Mice,
pubmed-meshheading:10889358-Mice, Inbred C57BL,
pubmed-meshheading:10889358-Myelin P2 Protein,
pubmed-meshheading:10889358-Neoplasm Proteins,
pubmed-meshheading:10889358-Nerve Tissue Proteins,
pubmed-meshheading:10889358-Rabbits,
pubmed-meshheading:10889358-Recombinant Proteins,
pubmed-meshheading:10889358-Schistosoma,
pubmed-meshheading:10889358-Schistosomiasis,
pubmed-meshheading:10889358-Vaccination
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pubmed:year |
2000
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pubmed:articleTitle |
Vaccination of mice against schistosoma bovis with a recombinant fatty acid binding protein from Fasciola hepatica.
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pubmed:affiliation |
Lab. Parasitología, Facultad de Farmacia, Universidad de Salamanca, Avda Campo Charro s/n, 37007, Salamanca, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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