| pubmed-article:10888929 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10888929 | lifeskim:mentions | umls-concept:C0020179 | lld:lifeskim |
| pubmed-article:10888929 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:10888929 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:10888929 | lifeskim:mentions | umls-concept:C0291573 | lld:lifeskim |
| pubmed-article:10888929 | lifeskim:mentions | umls-concept:C0534519 | lld:lifeskim |
| pubmed-article:10888929 | lifeskim:mentions | umls-concept:C0026187 | lld:lifeskim |
| pubmed-article:10888929 | lifeskim:mentions | umls-concept:C0026565 | lld:lifeskim |
| pubmed-article:10888929 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10888929 | lifeskim:mentions | umls-concept:C0205421 | lld:lifeskim |
| pubmed-article:10888929 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10888929 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10888929 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10888929 | pubmed:dateCreated | 2000-7-31 | lld:pubmed |
| pubmed-article:10888929 | pubmed:abstractText | Huntington disease is an autosomal dominant neurodegenerative disease with no effective treatment. Minocycline is a tetracycline derivative with proven safety. After ischemia, minocycline inhibits caspase-1 and inducible nitric oxide synthetase upregulation, and reduces infarction. As caspase-1 and nitric oxide seem to play a role in Huntington disease, we evaluated the therapeutic efficacy of minocycline in the R6/2 mouse model of Huntington disease. We report that minocycline delays disease progression, inhibits caspase-1 and caspase-3 mRNA upregulation, and decreases inducible nitric oxide synthetase activity. In addition, effective pharmacotherapy in R6/2 mice requires caspase-1 and caspase-3 inhibition. This is the first demonstration of caspase-1 and caspase-3 transcriptional regulation in a Huntington disease model. | lld:pubmed |
| pubmed-article:10888929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10888929 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10888929 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10888929 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10888929 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10888929 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:YUH IHI | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:ChenMM | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:FerranteR JRJ | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:MADD | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:VonsattelJ... | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:ObaM SMS | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:ZinKK | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:BiasGG | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:HerschS MSM | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:FriedlanderR... | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:HobbsWW | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:OngV YVY | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:FinnK CKC | lld:pubmed |
| pubmed-article:10888929 | pubmed:author | pubmed-author:FarrellL ALA | lld:pubmed |
| pubmed-article:10888929 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10888929 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:10888929 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10888929 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10888929 | pubmed:pagination | 797-801 | lld:pubmed |
| pubmed-article:10888929 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:10888929 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10888929 | pubmed:articleTitle | Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. | lld:pubmed |
| pubmed-article:10888929 | pubmed:affiliation | Neuroapoptosis Laboratory, Neurosurgical Service, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. | lld:pubmed |
| pubmed-article:10888929 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10888929 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10888929 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10888929 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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