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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2000-10-11
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pubmed:abstractText |
5-n-Pentyl oxadiazole substituted benzenesulfonamide 8 is a potent and selective beta3 adrenergic receptor agonist (beta3 EC50 = 23 nM, beta1 IC50 = 3000 nM, beta2 IC50 = 3000 nM). The compound has high oral bioavailability in dogs (62%) and rats (36%) and is among the most orally bioavailable beta3 adrenergic receptor agonists reported to date.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BiftuTT,
pubmed-author:CandeloreM RMR,
pubmed-author:CascieriM AMA,
pubmed-author:ColwellL FLFJr,
pubmed-author:DenkHH,
pubmed-author:FeeneyW PWP,
pubmed-author:FengD DDD,
pubmed-author:FisherM HMH,
pubmed-author:ForrestM JMJ,
pubmed-author:IRAG HGH,
pubmed-author:MacIntyreD EDE,
pubmed-author:MillerR RRR,
pubmed-author:StearnsR ARA,
pubmed-author:StraderC DCD,
pubmed-author:TothKK,
pubmed-author:WeberA EAE,
pubmed-author:WyvrattM JMJ
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1427-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10888324-Administration, Oral,
pubmed-meshheading:10888324-Adrenergic beta-3 Receptor Agonists,
pubmed-meshheading:10888324-Adrenergic beta-Agonists,
pubmed-meshheading:10888324-Animals,
pubmed-meshheading:10888324-Biological Availability,
pubmed-meshheading:10888324-CHO Cells,
pubmed-meshheading:10888324-Cricetinae,
pubmed-meshheading:10888324-Dogs,
pubmed-meshheading:10888324-Drug Design,
pubmed-meshheading:10888324-Humans,
pubmed-meshheading:10888324-Molecular Structure,
pubmed-meshheading:10888324-Oxadiazoles,
pubmed-meshheading:10888324-Rats,
pubmed-meshheading:10888324-Structure-Activity Relationship
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pubmed:year |
2000
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pubmed:articleTitle |
Discovery of an orally bioavailable alkyl oxadiazole beta3 adrenergic receptor agonist.
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pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway NJ 07065, USA. danqing_feng@merck.com
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pubmed:publicationType |
Journal Article
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