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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0021758,
umls-concept:C0027428,
umls-concept:C0205276,
umls-concept:C0214743,
umls-concept:C0220781,
umls-concept:C0238614,
umls-concept:C0439098,
umls-concept:C0700624,
umls-concept:C1519595,
umls-concept:C1883254,
umls-concept:C2348480
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pubmed:issue |
1 Pt 1
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pubmed:dateCreated |
2000-8-9
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pubmed:abstractText |
The production of epsilon germline gene transcripts (Iepsilon(+)/Cepsilon(+) RNA) precedes class switch recombination to IgE and is induced by IL-4 and/or IL-13. Although Iepsilon and Cepsilon RNA(+) B cells have been identified within nasal tissue after in vivo allergen exposure, suggesting local germline transcription, whether these were resident or infiltrating B lymphocytes was not clear.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0091-6749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
46-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10887304-Allergens,
pubmed-meshheading:10887304-Antigens, CD20,
pubmed-meshheading:10887304-B-Lymphocytes,
pubmed-meshheading:10887304-Culture Techniques,
pubmed-meshheading:10887304-Humans,
pubmed-meshheading:10887304-Immunoglobulin Constant Regions,
pubmed-meshheading:10887304-Immunoglobulin Switch Region,
pubmed-meshheading:10887304-Immunoglobulin epsilon-Chains,
pubmed-meshheading:10887304-Immunohistochemistry,
pubmed-meshheading:10887304-Interleukin-13,
pubmed-meshheading:10887304-Interleukin-4,
pubmed-meshheading:10887304-Mast Cells,
pubmed-meshheading:10887304-Nasal Mucosa,
pubmed-meshheading:10887304-RNA, Messenger,
pubmed-meshheading:10887304-T-Lymphocytes,
pubmed-meshheading:10887304-Transcription, Genetic
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pubmed:year |
2000
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pubmed:articleTitle |
Local synthesis of epsilon germline gene transcripts, IL-4, and IL-13 in allergic nasal mucosa after ex vivo allergen exposure.
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pubmed:affiliation |
Meakins-Christie Laboratories and the Jewish General Hospital, McGill University, and the Nôtre Dame Hospital, Univérsité de Montréal, Montreal.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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