| pubmed-article:10886396 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10886396 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:10886396 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:10886396 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:10886396 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10886396 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10886396 | pubmed:dateCreated | 2000-7-18 | lld:pubmed |
| pubmed-article:10886396 | pubmed:abstractText | To determine whether the paracrine secretion of interleukin (IL)-12 can efficiently convert immune responses characterized by high levels of synthesis of IL-4 and immunoglobulin E (IgE) into T helper 1 (Th1)-dominated responses, 3T3 fibroblasts were stably transfected to secrete IL-12 (480 units/10(6) cells/48 hr). Their effects on the T helper cell-mediated immune response were investigated in ovalbumin (OVA)-primed mice. Free mouse recombinant IL-12 was included as a control group. IL-12-secreting fibroblasts (3T3/IL-12) were more effective than free recombinant IL-12 at increasing OVA-specific interferon-gamma (IFN-gamma) production and decreasing OVA-specific IL-4 production in CD4+ T cells. In addition, injection with 3T3/IL-12 cells significantly increased anti-OVA immunoglobulin G2a (IgG2a) levels and decreased anti-OVA IgE levels in OVA-primed mice. This work suggests that IL-12-secreting fibroblasts can efficiently induce an antigen-specific Th1 response and may be beneficial in the treatment of diseases caused by undesirable T helper 2 (Th2)-dominated responses, including allergic diseases. | lld:pubmed |
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| pubmed-article:10886396 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10886396 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10886396 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10886396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10886396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10886396 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10886396 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10886396 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:10886396 | pubmed:author | pubmed-author:CHUK MKM | lld:pubmed |
| pubmed-article:10886396 | pubmed:author | pubmed-author:CHUT STS | lld:pubmed |
| pubmed-article:10886396 | pubmed:author | pubmed-author:HwangS YSY | lld:pubmed |
| pubmed-article:10886396 | pubmed:author | pubmed-author:ShinB ABA | lld:pubmed |
| pubmed-article:10886396 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10886396 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:10886396 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10886396 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10886396 | pubmed:pagination | 203-8 | lld:pubmed |
| pubmed-article:10886396 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10886396 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10886396 | pubmed:articleTitle | Efficient induction of an antigen-specific, T helper type 1 immune response by interleukin-12-secreting fibroblasts. | lld:pubmed |
| pubmed-article:10886396 | pubmed:affiliation | College of Pharmacy and College of Medicine, Chonnam National University, Kwangju, Republic of Korea. | lld:pubmed |
| pubmed-article:10886396 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10886396 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10886396 | lld:pubmed |
