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pubmed-article:10886124pubmed:abstractTextTerodiline has concentration dependent QT prolonging effects and thus the potential for cardiotoxicity. Pharmacogenetic variation in terodiline metabolism could be responsible for cardiotoxicity. We sought to determine whether CYP2D6 (debrisoquine hydroxylase) or CYP2C19 (S-mephenytoin hydroxylase) status is a risk factor for terodiline cardiotoxicity.lld:pubmed
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pubmed-article:10886124pubmed:articleTitleCYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system.lld:pubmed
pubmed-article:10886124pubmed:affiliationDepartment of Pharmacological Sciences, University of Newcastle upon Tyne, UK. g.a.ford@ncl.ac.uklld:pubmed
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