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rdf:type |
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lifeskim:mentions |
umls-concept:C0017431,
umls-concept:C0030705,
umls-concept:C0057223,
umls-concept:C0076126,
umls-concept:C0205396,
umls-concept:C0221205,
umls-concept:C0876994,
umls-concept:C0947504,
umls-concept:C1332828,
umls-concept:C1332830,
umls-concept:C1553467
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pubmed:issue |
1
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pubmed:dateCreated |
2000-9-14
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pubmed:abstractText |
Terodiline has concentration dependent QT prolonging effects and thus the potential for cardiotoxicity. Pharmacogenetic variation in terodiline metabolism could be responsible for cardiotoxicity. We sought to determine whether CYP2D6 (debrisoquine hydroxylase) or CYP2C19 (S-mephenytoin hydroxylase) status is a risk factor for terodiline cardiotoxicity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-10022751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-1623896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-1677700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-1688241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-2582539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-3433799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-3965205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-7617541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-7662454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-7969038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-8195181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-8689817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-8791778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-8873222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10886124-9110363
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Butylamines,
http://linkedlifedata.com/resource/pubmed/chemical/CYP2C19 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2D6,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Debrisoquin,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Parasympatholytics,
http://linkedlifedata.com/resource/pubmed/chemical/terodiline
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
77-80
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10886124-Aged,
pubmed-meshheading:10886124-Aged, 80 and over,
pubmed-meshheading:10886124-Alleles,
pubmed-meshheading:10886124-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:10886124-Butylamines,
pubmed-meshheading:10886124-Cytochrome P-450 CYP2D6,
pubmed-meshheading:10886124-Cytochrome P-450 Enzyme System,
pubmed-meshheading:10886124-DNA,
pubmed-meshheading:10886124-Debrisoquin,
pubmed-meshheading:10886124-Female,
pubmed-meshheading:10886124-Follow-Up Studies,
pubmed-meshheading:10886124-Gene Frequency,
pubmed-meshheading:10886124-Genotype,
pubmed-meshheading:10886124-Heart,
pubmed-meshheading:10886124-Humans,
pubmed-meshheading:10886124-Male,
pubmed-meshheading:10886124-Mixed Function Oxygenases,
pubmed-meshheading:10886124-Parasympatholytics,
pubmed-meshheading:10886124-Polymerase Chain Reaction,
pubmed-meshheading:10886124-Polymorphism, Genetic,
pubmed-meshheading:10886124-Tachycardia, Ventricular,
pubmed-meshheading:10886124-Torsades de Pointes
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pubmed:year |
2000
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pubmed:articleTitle |
CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system.
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pubmed:affiliation |
Department of Pharmacological Sciences, University of Newcastle upon Tyne, UK. g.a.ford@ncl.ac.uk
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pubmed:publicationType |
Journal Article
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