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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2000-9-22
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pubmed:abstractText |
The systemic anti-inflammatory effect induced by antidromic sensory nerve stimulation was investigated in rats and guinea-pigs. In atropine-pretreated rats, bilateral antidromic stimulation of vagal afferent fibres (8 Hz, 20 min, at C-fibre strength) inhibited plasma extravasation induced by 1% mustard oil on the acutely denervated hindlegs by 36.45+/-3.95%. Both the prevention of this inhibitory effect by cysteamine pretreatment and the stimulation-evoked rise of plasma somatostatin-like immunoreactivity in the two species suggest a mediator role of neural somatostatin. Since this response was blocked by systemic capsaicin pretreatment and slightly reduced after subdiaphragmal vagotomy, participation of thoracic capsaicin-sensitive afferents is indicated. In guinea-pigs pretreated with guanethidine and pipecuronium, antidromic sciatic nerve stimulation induced 45.46+/-5.08% inhibition on the contralateral leg and increased plasma somatostatin-like immunoreactivity. It is concluded that somatostatin released from the activated vagal capsaicin-sensitive sensory nerve terminals of the rat and somatic nerves of the guinea-pigs exerts a systemic humoral function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
399
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10884527-Afferent Pathways,
pubmed-meshheading:10884527-Animals,
pubmed-meshheading:10884527-Anti-Inflammatory Agents,
pubmed-meshheading:10884527-Blood Pressure,
pubmed-meshheading:10884527-Capillary Permeability,
pubmed-meshheading:10884527-Capsaicin,
pubmed-meshheading:10884527-Electric Stimulation,
pubmed-meshheading:10884527-Extravasation of Diagnostic and Therapeutic Materials,
pubmed-meshheading:10884527-Female,
pubmed-meshheading:10884527-Guanethidine,
pubmed-meshheading:10884527-Guinea Pigs,
pubmed-meshheading:10884527-Heart Rate,
pubmed-meshheading:10884527-Hindlimb,
pubmed-meshheading:10884527-Inflammation,
pubmed-meshheading:10884527-Mustard Plant,
pubmed-meshheading:10884527-Nerve Fibers,
pubmed-meshheading:10884527-Pipecuronium,
pubmed-meshheading:10884527-Plant Extracts,
pubmed-meshheading:10884527-Plant Oils,
pubmed-meshheading:10884527-Rats,
pubmed-meshheading:10884527-Rats, Wistar,
pubmed-meshheading:10884527-Sciatic Nerve,
pubmed-meshheading:10884527-Skin,
pubmed-meshheading:10884527-Somatostatin,
pubmed-meshheading:10884527-Vagus Nerve
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pubmed:year |
2000
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pubmed:articleTitle |
Systemic anti-inflammatory effect of somatostatin released from capsaicin-sensitive vagal and sciatic sensory fibres of the rat and guinea-pig.
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pubmed:affiliation |
Department of Pharmacology and Pharmacotherapy, University Medical School of Pécs, H-7601 P.O.Box 99, Pécs, Hungary.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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