Linked Life Data

10883360

Source:http://linkedlifedata.com/resource/pubmed/id/10883360

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-8-14
pubmed:abstractText
Sepsis and SIRS are characterised by increased hepatosplanchnic blood flow and oxygen transport due to sepsis-associated hypermetabolism with enhanced oxygen uptake. Regional hypermetabolism may be linked with a mismatch of oxygen availability and demand potentially resulting in a pathological splanchnic oxygen uptake/supply dependency. Splanchnic hypermetabolism has been hypothesised to be due to increased hepatic gluconeogenesis caused by accelerated glucose precursor uptake resulting from increased release from the peripheral tissues. This increased precursor efflux is triggered by cytokines. The response of splanchnic haemodynamics and oxygen kinetics, however, to therapeutic interventions does not necessarily parallel the different metabolic pathways. Therefore, understanding of both tissue perfusion and oxygenation as well as metabolism is pivotal for evaluating the effects of different therapeutic strategies in intensive care medicine.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0003-2417
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
451-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
[The effect of hepatosplanchnic circulation in treatment of trauma and sepsis. Beyond O2-supply O2-uptake relationship?].
pubmed:affiliation
Sektion Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Universitätsklinik für Anästhesiologie, Universität Ulm. karl.traeger@medizin.uni-ulm.de
pubmed:publicationType
Journal Article, English Abstract, Review