Source:http://linkedlifedata.com/resource/pubmed/id/10882843
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2000-9-6
|
| pubmed:abstractText |
There has been increasing evidence that deranged superoxide dismutase (SOD) activities might be a risk factor for schizophrenia and/or tardive dyskinesia (TD). In the present study, we investigated the genetic association between a functional polymorphism (Ala-9Val) in the human manganese (Mn) SOD gene and schizophrenia or TD (192 schizophrenics: 39 with TD and 153 without TD; 141 controls). No significant differences in the allelic or genotypic distribution between schizophrenics and controls were observed. However, we did find a significant difference in genotypic distribution between schizophrenics with and those without TD (p =. 03). Moreover, decreased -9Ala (mutant) allele was found among patients with TD (p =.02; odds ratio = 0.29; 95% confidence interval = 0.10-0.83). In conjunction with previous findings of increased free radicals and decreased SOD activities in TD subjects, these results suggest that the -9Ala (high activity) MnSOD allele may play a role in protecting against susceptibility to TD in schizophrenics.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0893-133X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
170-7
|
| pubmed:dateRevised |
2011-5-18
|
| pubmed:meshHeading |
pubmed-meshheading:10882843-Age Distribution,
pubmed-meshheading:10882843-Alleles,
pubmed-meshheading:10882843-Case-Control Studies,
pubmed-meshheading:10882843-Comorbidity,
pubmed-meshheading:10882843-Dyskinesia, Drug-Induced,
pubmed-meshheading:10882843-Female,
pubmed-meshheading:10882843-Gene Frequency,
pubmed-meshheading:10882843-Humans,
pubmed-meshheading:10882843-Japan,
pubmed-meshheading:10882843-Logistic Models,
pubmed-meshheading:10882843-Male,
pubmed-meshheading:10882843-Middle Aged,
pubmed-meshheading:10882843-Models, Statistical,
pubmed-meshheading:10882843-Odds Ratio,
pubmed-meshheading:10882843-Polymorphism, Genetic,
pubmed-meshheading:10882843-Schizophrenia,
pubmed-meshheading:10882843-Sensitivity and Specificity,
pubmed-meshheading:10882843-Sex Distribution,
pubmed-meshheading:10882843-Superoxide Dismutase
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Manganese superoxide dismutase gene polymorphism and schizophrenia: relation to tardive dyskinesia.
|
| pubmed:affiliation |
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
|
| pubmed:publicationType |
Journal Article
|