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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0023689,
umls-concept:C0037083,
umls-concept:C0041538,
umls-concept:C0105770,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0218349,
umls-concept:C0441655,
umls-concept:C0597357,
umls-concept:C1710082,
umls-concept:C2911684
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pubmed:issue |
5
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pubmed:dateCreated |
2000-7-13
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pubmed:abstractText |
Beta-transducing repeat-containing protein (betaTrCP) targets the ubiquitination and subsequent degradation of both beta-catenin and IkappaB, thereby playing an important role in beta-catenin/Tcf and NF-kappaB-dependent signaling. Here evidence is presented that beta-catenin/Tcf signaling elevates the expression of betaTrCP mRNA and protein in a Tcf-dependent manner, which does not require betaTrCP transcription. Induction of betaTrCP expression by the beta-catenin/Tcf pathway results in an accelerated degradation of the wild-type beta-catenin, suggesting that the negative feedback loop regulation may control the beta-catenin/Tcf pathway. This signaling also upregulated NF-kappaB transactivation without affecting the activity of IkappaB kinase, thereby establishing that the maintenance of the betaTrCP level is important for coordination between beta-catenin/Tcf and NF-kappaB signaling.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BTRC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TCF Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/TCF7L2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor 7-Like 2...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Transducin Repeat-Containing...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
877-82
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10882123-Cytoskeletal Proteins,
pubmed-meshheading:10882123-GTP-Binding Proteins,
pubmed-meshheading:10882123-HeLa Cells,
pubmed-meshheading:10882123-Humans,
pubmed-meshheading:10882123-Intestinal Mucosa,
pubmed-meshheading:10882123-Intestine, Large,
pubmed-meshheading:10882123-Ligases,
pubmed-meshheading:10882123-NF-kappa B,
pubmed-meshheading:10882123-Proto-Oncogene Proteins,
pubmed-meshheading:10882123-Signal Transduction,
pubmed-meshheading:10882123-TCF Transcription Factors,
pubmed-meshheading:10882123-Trans-Activators,
pubmed-meshheading:10882123-Transcription Factor 7-Like 2 Protein,
pubmed-meshheading:10882123-Transcription Factors,
pubmed-meshheading:10882123-Transcriptional Activation,
pubmed-meshheading:10882123-Ubiquitin-Protein Ligases,
pubmed-meshheading:10882123-Ubiquitins,
pubmed-meshheading:10882123-Up-Regulation,
pubmed-meshheading:10882123-Wnt2 Protein,
pubmed-meshheading:10882123-beta Catenin,
pubmed-meshheading:10882123-beta-Transducin Repeat-Containing Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor.
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pubmed:affiliation |
AMC Cancer Research Center, Denver, Colorado 80214, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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