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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
2000-8-8
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pubmed:abstractText |
Paclitaxel has been difficult to evaluate in preclinical tumor model systems because its poor solubility requires a Cremophor EL formulation, which results in lethal anaphylaxis. We tested the effectiveness of a novel polymeric micellar paclitaxel on androgen-independent tumor growth in the LNCaP tumor model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
156-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10881025-Animals,
pubmed-meshheading:10881025-Antibodies, Monoclonal,
pubmed-meshheading:10881025-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:10881025-Apoptosis,
pubmed-meshheading:10881025-Blotting, Western,
pubmed-meshheading:10881025-Electrophoresis, Agar Gel,
pubmed-meshheading:10881025-Gentian Violet,
pubmed-meshheading:10881025-Humans,
pubmed-meshheading:10881025-Immunoenzyme Techniques,
pubmed-meshheading:10881025-In Situ Nick-End Labeling,
pubmed-meshheading:10881025-Male,
pubmed-meshheading:10881025-Mice,
pubmed-meshheading:10881025-Mice, Inbred BALB C,
pubmed-meshheading:10881025-Mice, Nude,
pubmed-meshheading:10881025-Micelles,
pubmed-meshheading:10881025-Orchiectomy,
pubmed-meshheading:10881025-Paclitaxel,
pubmed-meshheading:10881025-Phosphorylation,
pubmed-meshheading:10881025-Prostate-Specific Antigen,
pubmed-meshheading:10881025-Prostatic Neoplasms,
pubmed-meshheading:10881025-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:10881025-Tumor Cells, Cultured
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pubmed:year |
2000
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|
pubmed:articleTitle |
Polymeric micellar paclitaxel phosphorylates Bcl-2 and induces apoptotic regression of androgen-independent LNCaP prostate tumors.
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pubmed:affiliation |
Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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