Source:http://linkedlifedata.com/resource/pubmed/id/10878386
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2000-8-3
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| pubmed:abstractText |
Intranasal infection of mice with the murine gamma-herpesvirus MHV-68 results in an acute lytic infection in the lung, followed by the establishment of lifelong latency. Development of an infectious mononucleosis-like syndrome correlates with the establishment of latency and is characterized by splenomegaly and the appearance of activated CD8+ T cells in the peripheral blood. Interestingly, a large population of activated CD8+ T cells in the peripheral blood expresses the V beta 4+ element in their TCR. In this report we show that MHV-68 latency in the spleen after intranasal infection is harbored in three APC types: B cells, macrophages, and dendritic cells. Surprisingly, since latency has not previously been described in dendritic cells, these cells harbored the highest frequency of latent virus. Among B cells, latency was preferentially associated with activated B cells expressing the phenotype of germinal center B cells, thus formally linking the previously reported association of latency gene expression and germinal centers to germinal center B cells. Germinal center formation, however, was not required for the establishment of latency. Significantly, although three cell types were latently infected, the ability to stimulate V beta 4+CD8+ T cell hybridomas was limited to latently infected, activated B cells.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
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| pubmed:volume |
165
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1074-81
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10878386-Animals,
pubmed-meshheading:10878386-B-Lymphocytes,
pubmed-meshheading:10878386-CD8-Positive T-Lymphocytes,
pubmed-meshheading:10878386-Dendritic Cells,
pubmed-meshheading:10878386-Gammaherpesvirinae,
pubmed-meshheading:10878386-Germinal Center,
pubmed-meshheading:10878386-Hybridomas,
pubmed-meshheading:10878386-Infectious Mononucleosis,
pubmed-meshheading:10878386-Ligands,
pubmed-meshheading:10878386-Lymphocyte Activation,
pubmed-meshheading:10878386-Lymphocyte Count,
pubmed-meshheading:10878386-Macrophage Activation,
pubmed-meshheading:10878386-Macrophages,
pubmed-meshheading:10878386-Mice,
pubmed-meshheading:10878386-Mice, Inbred BALB C,
pubmed-meshheading:10878386-Mice, Inbred C57BL,
pubmed-meshheading:10878386-Mice, Mutant Strains,
pubmed-meshheading:10878386-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:10878386-Spleen,
pubmed-meshheading:10878386-Syndrome,
pubmed-meshheading:10878386-T-Lymphocytes,
pubmed-meshheading:10878386-Virus Latency
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Latent murine gamma-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages.
|
| pubmed:affiliation |
Department of Immunology, Program in Viral Oncogenesis and Tumor Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|