Source:http://linkedlifedata.com/resource/pubmed/id/10878252
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2000-8-2
|
| pubmed:abstractText |
Nuclear hormone receptors are transcription factors regulated by lipophilic ligands. These hormones bind to their nuclear receptor targets using an induced fit mechanism that triggers a large conformational change and generates the proper surface for the binding of protein coactivators. The molecular details of the various steps of this activation process or its inhibition by antagonists are now understood for several nuclear receptors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0014-5793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
30
|
| pubmed:volume |
476
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
62-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10878252-Animals,
pubmed-meshheading:10878252-Hormones,
pubmed-meshheading:10878252-Ligands,
pubmed-meshheading:10878252-Models, Molecular,
pubmed-meshheading:10878252-Protein Conformation,
pubmed-meshheading:10878252-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:10878252-Receptors, Retinoic Acid
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Ligand-protein interactions in nuclear receptors of hormones.
|
| pubmed:affiliation |
Laboratoire de Biologie et Génomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 1, rue Laurent Fries, P.O. Box 163, F-67404 Cedex, Illkirch, France.
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|