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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1977-3-15
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pubmed:abstractText |
Extensive physiological evaluation of lung function were conducted in two groups of asymptomatic individuals with deficiencies of alpha1-antitrypsin: seven subjects with phenotype Pi SZ and six subjects with phenotype Pi Z. Four symptomatic individuals of Pi Z type were also investigated. The asymptomatic individuals of both SZ and Z phenotypes revealed reduction of elastic recoil, hypoventilation and hypoperfusion of the lung bases with increased closing and nitogen wash-out volumes. No signs of bronchial obstruction were observed. The asymptomatic Pi SZ subjects revealed as many signs of subclinical disease as did the asymptomatic Pi Z subjects. These data suggest that Pi SZ subjects are at increased risk of emphysema similar to Pi Z subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
0036-5572
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
267-80
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:1087749-Adult,
pubmed-meshheading:1087749-Bronchitis,
pubmed-meshheading:1087749-Dyspnea,
pubmed-meshheading:1087749-Expiratory Reserve Volume,
pubmed-meshheading:1087749-Female,
pubmed-meshheading:1087749-Forced Expiratory Volume,
pubmed-meshheading:1087749-Functional Residual Capacity,
pubmed-meshheading:1087749-Humans,
pubmed-meshheading:1087749-Lung Compliance,
pubmed-meshheading:1087749-Lung Volume Measurements,
pubmed-meshheading:1087749-Male,
pubmed-meshheading:1087749-Maximal Voluntary Ventilation,
pubmed-meshheading:1087749-Middle Aged,
pubmed-meshheading:1087749-Phenotype,
pubmed-meshheading:1087749-Pulmonary Emphysema,
pubmed-meshheading:1087749-Respiration,
pubmed-meshheading:1087749-Smoking,
pubmed-meshheading:1087749-Vital Capacity,
pubmed-meshheading:1087749-alpha 1-Antitrypsin Deficiency
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pubmed:year |
1976
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pubmed:articleTitle |
Lung function studies in asymptomatic individuals with moderately (Pi SZ) and severely (Pi Z) reduced levels of alpha1-antitrypsin.
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pubmed:publicationType |
Journal Article
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