Source:http://linkedlifedata.com/resource/pubmed/id/10875586
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2000-7-17
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| pubmed:abstractText |
Previous studies have shown that defibrotide, a polydeoxyribonucleotide obtained by depolymerization of DNA from porcine tissues, has important protective effects on myocardial ischemia, which may be associated with a prostacyclin-related mechanism. The purpose of this study was to investigate the direct effects of defibrotide (given in cardioplegia or after ischemia) on a model of rat heart recovery after cardioplegia followed by ischemia/reperfusion injury.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0886-0440
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
334-41
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| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10875586-Animals,
pubmed-meshheading:10875586-Fibrinolytic Agents,
pubmed-meshheading:10875586-Heart Arrest, Induced,
pubmed-meshheading:10875586-Male,
pubmed-meshheading:10875586-Myocardial Reperfusion Injury,
pubmed-meshheading:10875586-Myocardium,
pubmed-meshheading:10875586-Organ Preservation,
pubmed-meshheading:10875586-Polydeoxyribonucleotides,
pubmed-meshheading:10875586-Rats,
pubmed-meshheading:10875586-Rats, Wistar,
pubmed-meshheading:10875586-Ventricular Function, Left
|
| pubmed:articleTitle |
Protectant activity of defibrotide in cardioplegia followed by ischemia/reperfusion injury in the isolated rat heart.
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| pubmed:affiliation |
Department of Pharmacology, Chemotherapy and Medical Toxicology, Institute of Pharmacological Science, University of Milan, Italy.
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| pubmed:publicationType |
Journal Article
|