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rdf:type |
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lifeskim:mentions |
umls-concept:C0015576,
umls-concept:C0016129,
umls-concept:C0017262,
umls-concept:C0026845,
umls-concept:C0086418,
umls-concept:C0205250,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C0680022,
umls-concept:C1171362,
umls-concept:C1423084,
umls-concept:C1515670
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pubmed:issue |
1
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pubmed:dateCreated |
2000-7-27
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pubmed:databankReference |
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pubmed:abstractText |
Initially characterized as Drosophila developmental regulators, the BTB/POZ and zinc finger proteins (BTB/POZ-ZF) constitute a growing family of proteins with gene expression regulatory functions since they have been shown to be involved in both transcriptional activation and repression of various genes in a broad range of species, including mammals. Here we report the cloning of a novel human transcript, coding for a 68-kDa deduced BTB/POZ-ZF protein. This molecule, called myoneurin on the basis of its prevalent expression in the neuromuscular system, contains an amino-terminal BTB/POZ domain and eight tandemly repeated zinc-finger motifs of the C(2)H(2) type. The murine myoneurin, identified in the mouse embryo, is highly homologous to the human protein.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
273
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
385-91
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10873615-Aging,
pubmed-meshheading:10873615-Amino Acid Sequence,
pubmed-meshheading:10873615-Animals,
pubmed-meshheading:10873615-Base Sequence,
pubmed-meshheading:10873615-Cloning, Molecular,
pubmed-meshheading:10873615-Embryo, Mammalian,
pubmed-meshheading:10873615-Gene Expression Profiling,
pubmed-meshheading:10873615-Humans,
pubmed-meshheading:10873615-Kruppel-Like Transcription Factors,
pubmed-meshheading:10873615-Mice,
pubmed-meshheading:10873615-Molecular Sequence Data,
pubmed-meshheading:10873615-Multigene Family,
pubmed-meshheading:10873615-Muscle, Skeletal,
pubmed-meshheading:10873615-Organ Specificity,
pubmed-meshheading:10873615-Protein Structure, Tertiary,
pubmed-meshheading:10873615-RNA, Messenger,
pubmed-meshheading:10873615-Repetitive Sequences, Amino Acid,
pubmed-meshheading:10873615-Repressor Proteins,
pubmed-meshheading:10873615-Sequence Alignment,
pubmed-meshheading:10873615-Sequence Homology, Amino Acid,
pubmed-meshheading:10873615-Transcription Factors,
pubmed-meshheading:10873615-Zinc Fingers
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pubmed:year |
2000
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pubmed:articleTitle |
Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle.
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pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale, U488, Bâtiment Gregory Pincus, 80 rue du Général Leclerc, Le Kremlin Bicêtre cedex, 94276, France. alliel@infobiogen.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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