Linked Life Data

10873513

Source:http://linkedlifedata.com/resource/pubmed/id/10873513

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-10-19
pubmed:abstractText
The effects of elevated PO(2) on flow-induced dilation of in situ skeletal muscle arterioles was assessed in cremaster muscle preparations from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. Blood flow increases in selected arterioles were initiated by occlusion of a parallel daughter branch from a parent arteriole. Changes in the diameter of the perfused arteriole were measured with a video micrometer and erythrocyte velocity was measured using optical Doppler velocimetry. Superfusate PO(2) was controlled by changing the O(2) concentration (0% O(2) or 21% O(2)) of the equilibration gas mixture. The increase in arteriolar diameter during occlusion was reduced in SHR compared to WKY rats, resulting in an elevated wall shear rate in SHR. Elevated PO(2) decreased flow-induced dilation in both groups and increased wall shear rate during parallel occlusion. An inhibitor of the formation of 20-HETE via cytochrome P450-4A enzymes (P450), dibromododecenyl methylsulfimide, minimized O(2)-induced constriction of arterioles and prevented the O(2)-induced decrease in flow-induced dilation and the increase in wall shear rate in both SHR and WKY rats. These results suggest that: (1) flow-induced dilation of in situ skeletal muscle arterioles is impaired in SHR compared to WKY, (2) elevated O(2) compromises flow-induced dilation in both groups, (3) 20-HETE contributes to both the O(2)-induced increases in resting tone and the reduced flow-induced dilation of cremasteric arterioles with elevated PO(2).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0026-2862
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Academic Press.
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-48
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:10873513-Alkane 1-Monooxygenase, pubmed-meshheading:10873513-Amides, pubmed-meshheading:10873513-Animals, pubmed-meshheading:10873513-Arterioles, pubmed-meshheading:10873513-Cytochrome P-450 Enzyme System, pubmed-meshheading:10873513-Enzyme Inhibitors, pubmed-meshheading:10873513-Hemorheology, pubmed-meshheading:10873513-Hydroxyeicosatetraenoic Acids, pubmed-meshheading:10873513-Hypertension, pubmed-meshheading:10873513-Male, pubmed-meshheading:10873513-Microcirculation, pubmed-meshheading:10873513-Microscopy, Video, pubmed-meshheading:10873513-Mixed Function Oxygenases, pubmed-meshheading:10873513-Muscle, Skeletal, pubmed-meshheading:10873513-Oxygen, pubmed-meshheading:10873513-Partial Pressure, pubmed-meshheading:10873513-Rats, pubmed-meshheading:10873513-Rats, Inbred SHR, pubmed-meshheading:10873513-Rats, Inbred WKY, pubmed-meshheading:10873513-Sulfones, pubmed-meshheading:10873513-Vasodilation
pubmed:year
2000
pubmed:articleTitle
Impairment of flow-induced dilation of skeletal muscle arterioles with elevated oxygen in normotensive and hypertensive rats.
pubmed:affiliation
Department of Physiology, Milwaukee, Wisconsin 53226, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.