Source:http://linkedlifedata.com/resource/pubmed/id/10873101
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2000-9-29
|
| pubmed:abstractText |
Phosphorothioate oligodeoxynucleotides with CpG motifs (CpG-ODNs) activate various immune cell subsets and induce production of numerous cytokines. To evaluate whether CpG-ODNs can induce rejection of established tumors, Lewis rats were inoculated intracerebrally with syngeneic CNS-1 glioma cells and subsequently injected with CpG-ODNs into the tumor bed. Although all of the control rats (n = 14) died within 23 days, 88% of the animals (n = 8) treated with a single CpG-ODN injection 5 days after tumor inoculation showed long-term survival (>90 days; P < 0.002). CpG-ODNs increased tumoral infiltration with macrophage/microglial cells, CD8, and natural killer lymphocytes. CpG-ODN-cured animals were further protected against a second tumor challenge. CpG-ODNs had no effect on a s.c. CNS1 tumor in nude mice, which suggested that CpG-ODN is not directly cytotoxic and that immunostimulation is required for the antitumoral effect. These findings suggest that intratumoral injections of CpG-ODNs represent a new immunotherapeutic approach in human gliomas, which overcome the need for the selection and purification of a tumoral antigen.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1078-0432
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2469-73
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| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10873101-Animals,
pubmed-meshheading:10873101-Antigens, CD8,
pubmed-meshheading:10873101-Brain Neoplasms,
pubmed-meshheading:10873101-Cancer Vaccines,
pubmed-meshheading:10873101-CpG Islands,
pubmed-meshheading:10873101-Glioma,
pubmed-meshheading:10873101-Humans,
pubmed-meshheading:10873101-Immunohistochemistry,
pubmed-meshheading:10873101-Killer Cells, Natural,
pubmed-meshheading:10873101-Macrophages,
pubmed-meshheading:10873101-Male,
pubmed-meshheading:10873101-Mice,
pubmed-meshheading:10873101-Mice, Nude,
pubmed-meshheading:10873101-Microglia,
pubmed-meshheading:10873101-Neoplasm Transplantation,
pubmed-meshheading:10873101-Oligonucleotides,
pubmed-meshheading:10873101-Rats,
pubmed-meshheading:10873101-Rats, Inbred Lew,
pubmed-meshheading:10873101-Time Factors,
pubmed-meshheading:10873101-Tumor Cells, Cultured
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Successful treatment of intracranial gliomas in rat by oligodeoxynucleotides containing CpG motifs.
|
| pubmed:affiliation |
Biologie des Interactions Neurones/Glie, Institut National de la Santé et de la Recherche Médicale U-495, Université Pierre Marie Curie, and Fédération de neurologie Mazarin, Paris, France. antoine.carpentier@psl.ap-hop-paris.fr
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|