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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2000-10-16
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pubmed:abstractText |
Glial-derived growth factor (GDNF), which is the ligand of RET is reported to be essential for the development of enteric nervous system. A GDNF knockout mouse model has shown that the gastric region is a critical passing site between GDNF-RET-independent neuroblasts (colonizing the esophagus) and GDNF-RET-dependent neuroblasts (colonizing the small and large bowel). The earliest GDNF site of production is the mesenchyme and the outer smooth muscle cell (SMC) layer of the developing bowel. In the mature gastrointestinal tract the presence of GDNF is restricted to enteric glial cells. The aim of this study was to investigate the expression of GDNF and RET in infantile hypertrophic pyloric stenosis (IHPS).
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GDNF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Cell Line-Derived...,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Cell Line-Derived...,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ret,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Ret oncogene protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-3468
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
835-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10873021-Drosophila Proteins,
pubmed-meshheading:10873021-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10873021-Glial Cell Line-Derived Neurotrophic Factor,
pubmed-meshheading:10873021-Glial Cell Line-Derived Neurotrophic Factor Receptors,
pubmed-meshheading:10873021-Humans,
pubmed-meshheading:10873021-Hypertrophy,
pubmed-meshheading:10873021-Immunohistochemistry,
pubmed-meshheading:10873021-Infant,
pubmed-meshheading:10873021-Infant, Newborn,
pubmed-meshheading:10873021-Muscle, Smooth,
pubmed-meshheading:10873021-Myenteric Plexus,
pubmed-meshheading:10873021-Nerve Growth Factors,
pubmed-meshheading:10873021-Nerve Tissue Proteins,
pubmed-meshheading:10873021-Proto-Oncogene Proteins,
pubmed-meshheading:10873021-Proto-Oncogene Proteins c-ret,
pubmed-meshheading:10873021-Pyloric Stenosis,
pubmed-meshheading:10873021-Pylorus,
pubmed-meshheading:10873021-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:10873021-Signal Transduction
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pubmed:year |
2000
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pubmed:articleTitle |
Glial-derived growth factor signaling pathway in infantile hypertrophic pyloric stenosis.
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pubmed:affiliation |
Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland.
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pubmed:publicationType |
Journal Article
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