Source:http://linkedlifedata.com/resource/pubmed/id/10872654
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2000-7-6
|
| pubmed:abstractText |
Low-grade intraosseous osteosarcoma is an uncommon form of bone cancer. It is occasionally difficult to recognize as a malignant tumor and is commonly misdiagnosed as a benign fibrous lesion. We retrospectively studied the records of 8 patients with low-grade intraosseous osteosarcoma in the files of the Tohoku Musculoskeletal Tumor Society in Japan. All tumors arose in the lower limb. The most common symptom was pain, with a duration exceeding 2 years in 4 patients. Radiologic findings, including those at magnetic resonance imaging (MRI), suggested malignancy in 5 lesions, whereas 3 were diagnosed as benign. Two patients initially presented with pathological fracture. The initial pathological diagnosis was malignant in 5 patients and benign in 3. All eight tumors were grade 1 in Broders' classification. The tumor showed a permeative pattern in all eight cases, but this pattern could not be confirmed in the multiple tiny fragments obtained as biopsy specimens in 3 cases. The number of silver-staining nucleolar organizer regions (AgNOR) per nucleus and MIB-1-positive rate were significantly higher in low-grade intraosseous osteosarcoma than in fibrous dysplasia, offering an advantage in differential diagnosis. Three patients (38%) developed high-grade sarcoma at the site of local recurrence after multiple intralesional excisions, and one of them died of the disease. The other 5 patients had a good clinical course after surgery with a wide margin. These findings indicate that preoperative diagnosis with radiologic investigation, including magnetic resonance (MR) imaging and histologic examination of biopsy specimens is essential in preparation for surgery with a wide margin, assuring a good clinical course, and the results of AgNOR and immunohistochemical MIB-1 staining might be helpful in differentiating low-grade intraosseous osteosarcoma from fibrous dysplasia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0046-8177
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
633-9
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10872654-Adolescent,
pubmed-meshheading:10872654-Adult,
pubmed-meshheading:10872654-Aged,
pubmed-meshheading:10872654-Antigens, Nuclear,
pubmed-meshheading:10872654-Bone Neoplasms,
pubmed-meshheading:10872654-Combined Modality Therapy,
pubmed-meshheading:10872654-Diagnosis, Differential,
pubmed-meshheading:10872654-Female,
pubmed-meshheading:10872654-Femoral Neoplasms,
pubmed-meshheading:10872654-Humans,
pubmed-meshheading:10872654-Immunohistochemistry,
pubmed-meshheading:10872654-Japan,
pubmed-meshheading:10872654-Ki-67 Antigen,
pubmed-meshheading:10872654-Male,
pubmed-meshheading:10872654-Middle Aged,
pubmed-meshheading:10872654-Nuclear Proteins,
pubmed-meshheading:10872654-Nucleolus Organizer Region,
pubmed-meshheading:10872654-Osteosarcoma,
pubmed-meshheading:10872654-Silver Staining
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Low-grade intraosseous osteosarcoma in northern Japan: advantage of AgNOR and MIB-1 staining in differential diagnosis.
|
| pubmed:affiliation |
Tohoku Musculoskeletal Tumor Society, Akita University School of Medicine, Japan.
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| pubmed:publicationType |
Journal Article
|