| pubmed-article:10865839 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10865839 | lifeskim:mentions | umls-concept:C0148199 | lld:lifeskim |
| pubmed-article:10865839 | lifeskim:mentions | umls-concept:C0378516 | lld:lifeskim |
| pubmed-article:10865839 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:10865839 | lifeskim:mentions | umls-concept:C1334306 | lld:lifeskim |
| pubmed-article:10865839 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:10865839 | pubmed:dateCreated | 2000-7-11 | lld:pubmed |
| pubmed-article:10865839 | pubmed:abstractText | The properties of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF in human umbilical vein endothelial cells (HUVECs) were investigated by using two newly developed blocking monoclonal antibodies (mAbs) against Flt-1 and KDR. VEGF stimulated the expression of transcription factor Ets-1 as well as matrix metalloproteinase-1 (MMP-1) and Flt-1 in HUVECs. The KDR/Flt-1 heterodimer and the KDR homodimer mediate the expression of Ets-1, MMP-1, and Flt-1. VEGF also stimulated DNA synthesis and migration of HUVECs. DNA synthesis is mediated by the same signaling system as the expression of Ets-1. In contrast, cell migration is regulated by two distinct signaling systems. The Flt-1 homodimer is required for actin reorganization. The KDR/Flt-1 heterodimer and the KDR homodimer are required for the assembly of vinculin in focal adhesion plaque by regulating the phosphorylation of focal adhesion kinase (FAK) and paxillin. | lld:pubmed |
| pubmed-article:10865839 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10865839 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10865839 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10865839 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10865839 | pubmed:month | May | lld:pubmed |
| pubmed-article:10865839 | pubmed:issn | 0077-8923 | lld:pubmed |
| pubmed-article:10865839 | pubmed:author | pubmed-author:ItoMM | lld:pubmed |
| pubmed-article:10865839 | pubmed:author | pubmed-author:SatoYY | lld:pubmed |
| pubmed-article:10865839 | pubmed:author | pubmed-author:ShibuyaMM | lld:pubmed |
| pubmed-article:10865839 | pubmed:author | pubmed-author:AbeMM | lld:pubmed |
| pubmed-article:10865839 | pubmed:author | pubmed-author:ROT KTK | lld:pubmed |
| pubmed-article:10865839 | pubmed:author | pubmed-author:KannoSS | lld:pubmed |
| pubmed-article:10865839 | pubmed:author | pubmed-author:ShitaraKK | lld:pubmed |
| pubmed-article:10865839 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10865839 | pubmed:volume | 902 | lld:pubmed |
| pubmed-article:10865839 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10865839 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10865839 | pubmed:pagination | 201-5; discussion 205-7 | lld:pubmed |
| pubmed-article:10865839 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10865839 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10865839 | pubmed:articleTitle | Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction. | lld:pubmed |
| pubmed-article:10865839 | pubmed:affiliation | Department of Vascular Biology, Tohoku University, Sendai, Japan. y-sato@idac.tohoku.ac.jp | lld:pubmed |
| pubmed-article:10865839 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10865839 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:10865839 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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