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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2000-7-11
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pubmed:abstractText |
The properties of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF in human umbilical vein endothelial cells (HUVECs) were investigated by using two newly developed blocking monoclonal antibodies (mAbs) against Flt-1 and KDR. VEGF stimulated the expression of transcription factor Ets-1 as well as matrix metalloproteinase-1 (MMP-1) and Flt-1 in HUVECs. The KDR/Flt-1 heterodimer and the KDR homodimer mediate the expression of Ets-1, MMP-1, and Flt-1. VEGF also stimulated DNA synthesis and migration of HUVECs. DNA synthesis is mediated by the same signaling system as the expression of Ets-1. In contrast, cell migration is regulated by two distinct signaling systems. The Flt-1 homodimer is required for actin reorganization. The KDR/Flt-1 heterodimer and the KDR homodimer are required for the assembly of vinculin in focal adhesion plaque by regulating the phosphorylation of focal adhesion kinase (FAK) and paxillin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ETS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Protein c-ets-1,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ets,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vascular Endothelial...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0077-8923
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
902
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-5; discussion 205-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10865839-Endothelial Growth Factors,
pubmed-meshheading:10865839-Endothelium, Vascular,
pubmed-meshheading:10865839-Gene Expression Regulation,
pubmed-meshheading:10865839-Humans,
pubmed-meshheading:10865839-Lymphokines,
pubmed-meshheading:10865839-Matrix Metalloproteinase 1,
pubmed-meshheading:10865839-Proto-Oncogene Protein c-ets-1,
pubmed-meshheading:10865839-Proto-Oncogene Proteins,
pubmed-meshheading:10865839-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:10865839-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:10865839-Receptors, Growth Factor,
pubmed-meshheading:10865839-Receptors, Vascular Endothelial Growth Factor,
pubmed-meshheading:10865839-Signal Transduction,
pubmed-meshheading:10865839-Transcription Factors,
pubmed-meshheading:10865839-Vascular Endothelial Growth Factor A,
pubmed-meshheading:10865839-Vascular Endothelial Growth Factor Receptor-1,
pubmed-meshheading:10865839-Vascular Endothelial Growth Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction.
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pubmed:affiliation |
Department of Vascular Biology, Tohoku University, Sendai, Japan. y-sato@idac.tohoku.ac.jp
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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