Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-8-2
pubmed:abstractText
Regional haemodynamic responses to recombinant murine or human leptin were assessed in conscious, chronically-instrumented, male, Long-Evans rats (350 - 450 g). Human, but not murine, leptin caused a slight hindquarters vasoconstriction, but neither peptide had any effect on mean arterial blood pressure or heart rate. In the presence of the beta(2)-adrenoceptor antagonist, ICI 118551, a hindquarters vasoconstrictor response to human leptin was not seen, and there was a tachycardia, as there was to murine leptin. The nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester, (L-NAME), did not influence the cardiovascular effects of murine or human leptin. The results indicate that the previously reported sympathoexcitatory effects of murine leptin in anaesthetized rats are not manifest as regional haemodynamic changes in conscious rats, and this is not due to beta(2)-adrenoceptor-mediated vasodilator mechanisms opposing any vasoconstrictor responses. Moreover, the ability of L-NAME to unmask a pressor effect of murine leptin in anaesthetized rats may not be apparent in the conscious state.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-10102710, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-10425201, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-10564240, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-1324051, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-1797333, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-1933136, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-2127552, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-2655481, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-2902805, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-6191142, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-7624776, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-7624777, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-7984236, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9087676, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9102398, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9119061, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9166685, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9218503, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9322991, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9392493, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9394003, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9438411, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9453337, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9622200, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9641546, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9732873, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9733517, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9815153, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9931161, http://linkedlifedata.com/resource/pubmed/commentcorrection/10864886-9931162
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
805-10
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:10864886-Adrenergic beta-Antagonists, pubmed-meshheading:10864886-Animals, pubmed-meshheading:10864886-Blood Circulation, pubmed-meshheading:10864886-Blood Pressure, pubmed-meshheading:10864886-Consciousness, pubmed-meshheading:10864886-Enzyme Inhibitors, pubmed-meshheading:10864886-Heart Rate, pubmed-meshheading:10864886-Hemodynamics, pubmed-meshheading:10864886-Hindlimb, pubmed-meshheading:10864886-Humans, pubmed-meshheading:10864886-Kidney, pubmed-meshheading:10864886-Leptin, pubmed-meshheading:10864886-Male, pubmed-meshheading:10864886-Mesentery, pubmed-meshheading:10864886-Mice, pubmed-meshheading:10864886-NG-Nitroarginine Methyl Ester, pubmed-meshheading:10864886-Nitric Oxide Synthase, pubmed-meshheading:10864886-Propanolamines, pubmed-meshheading:10864886-Rats, pubmed-meshheading:10864886-Rats, Long-Evans, pubmed-meshheading:10864886-Recombinant Proteins, pubmed-meshheading:10864886-Regional Blood Flow, pubmed-meshheading:10864886-Vascular Resistance
pubmed:year
2000
pubmed:articleTitle
Regional haemodynamic effects of recombinant murine or human leptin in conscious rats.
pubmed:affiliation
School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH.
pubmed:publicationType
Journal Article