| pubmed-article:10864874 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10864874 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:10864874 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10864874 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:10864874 | pubmed:issue | 5474 | lld:pubmed |
| pubmed-article:10864874 | pubmed:dateCreated | 2000-7-13 | lld:pubmed |
| pubmed-article:10864874 | pubmed:abstractText | Neuronal PAS domain protein 2 (NPAS2) is a basic helix-loop-helix (bHLH) PAS domain transcription factor expressed in multiple regions of the vertebrate brain. Targeted insertion of a beta-galactosidase reporter gene (lacZ) resulted in the production of an NPAS2-lacZ fusion protein and an altered form of NPAS2 lacking the bHLH domain. The neuroanatomical expression pattern of NPAS2-lacZ was temporally and spatially coincident with formation of the mature frontal association/limbic forebrain pathway. NPAS2-deficient mice were subjected to a series of behavioral tests and were found to exhibit deficits in the long-term memory arm of the cued and contextual fear task. Thus, NPAS2 may serve a dedicated regulatory role in the acquisition of specific types of memory. | lld:pubmed |
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| pubmed-article:10864874 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10864874 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10864874 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10864874 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10864874 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10864874 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:10864874 | pubmed:author | pubmed-author:ReichHH | lld:pubmed |
| pubmed-article:10864874 | pubmed:author | pubmed-author:McKnightS LSL | lld:pubmed |
| pubmed-article:10864874 | pubmed:author | pubmed-author:ZhangDD | lld:pubmed |
| pubmed-article:10864874 | pubmed:author | pubmed-author:ScottKK | lld:pubmed |
| pubmed-article:10864874 | pubmed:author | pubmed-author:GarcinJ NJN | lld:pubmed |
| pubmed-article:10864874 | pubmed:author | pubmed-author:Diaz-Arrastia... | lld:pubmed |
| pubmed-article:10864874 | pubmed:author | pubmed-author:RutterJJ | lld:pubmed |
| pubmed-article:10864874 | pubmed:author | pubmed-author:MichnoffCC | lld:pubmed |
| pubmed-article:10864874 | pubmed:author | pubmed-author:EstillS JSJ | lld:pubmed |
| pubmed-article:10864874 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10864874 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:10864874 | pubmed:volume | 288 | lld:pubmed |
| pubmed-article:10864874 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10864874 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10864874 | pubmed:pagination | 2226-30 | lld:pubmed |
| pubmed-article:10864874 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10864874 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10864874 | pubmed:articleTitle | Impaired cued and contextual memory in NPAS2-deficient mice. | lld:pubmed |
| pubmed-article:10864874 | pubmed:affiliation | Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. | lld:pubmed |
| pubmed-article:10864874 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10864874 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10864874 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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