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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5474
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pubmed:dateCreated |
2000-7-13
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pubmed:abstractText |
Neuronal PAS domain protein 2 (NPAS2) is a basic helix-loop-helix (bHLH) PAS domain transcription factor expressed in multiple regions of the vertebrate brain. Targeted insertion of a beta-galactosidase reporter gene (lacZ) resulted in the production of an NPAS2-lacZ fusion protein and an altered form of NPAS2 lacking the bHLH domain. The neuroanatomical expression pattern of NPAS2-lacZ was temporally and spatially coincident with formation of the mature frontal association/limbic forebrain pathway. NPAS2-deficient mice were subjected to a series of behavioral tests and were found to exhibit deficits in the long-term memory arm of the cued and contextual fear task. Thus, NPAS2 may serve a dedicated regulatory role in the acquisition of specific types of memory.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
288
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2226-30
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10864874-Animals,
pubmed-meshheading:10864874-Avoidance Learning,
pubmed-meshheading:10864874-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:10864874-Behavior, Animal,
pubmed-meshheading:10864874-Brain,
pubmed-meshheading:10864874-Conditioning (Psychology),
pubmed-meshheading:10864874-Cues,
pubmed-meshheading:10864874-Fear,
pubmed-meshheading:10864874-Gene Targeting,
pubmed-meshheading:10864874-Helix-Loop-Helix Motifs,
pubmed-meshheading:10864874-Learning,
pubmed-meshheading:10864874-Limbic System,
pubmed-meshheading:10864874-Male,
pubmed-meshheading:10864874-Memory,
pubmed-meshheading:10864874-Mice,
pubmed-meshheading:10864874-Nerve Tissue Proteins,
pubmed-meshheading:10864874-Prosencephalon,
pubmed-meshheading:10864874-Recombinant Fusion Proteins,
pubmed-meshheading:10864874-Touch,
pubmed-meshheading:10864874-Transcription Factors,
pubmed-meshheading:10864874-Transcriptional Activation,
pubmed-meshheading:10864874-Transfection,
pubmed-meshheading:10864874-beta-Galactosidase
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pubmed:year |
2000
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pubmed:articleTitle |
Impaired cued and contextual memory in NPAS2-deficient mice.
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pubmed:affiliation |
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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