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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2000-8-22
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pubmed:abstractText |
Murine models of gamma interferon (IFN-gamma) deficiency demonstrate the role of this cytokine in attenuating acute herpes simplex virus (HSV) disease; however, the effect of IFN-gamma on the establishment and maintenance of neuronal latency and viral reactivation is not known. Using the IFN-gamma knockout (GKO) model of IFN-gamma deficiency and sensitive quantitative PCR methods, we show that IFN-gamma significantly reduces the ganglion content of latent HSV-1 in BALB/c mice, which in turn delays viral time to reactivation following UV irradiation. Similar effects were not seen in the C57BL/6 strain. These results indicate that IFN-gamma significantly attenuates latent HSV infection in the mouse model of ocular infection but has no impact on the maintenance of latency or virus reactivation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-10233988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-10438344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-1314868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-1654309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-171586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-2506268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-7561104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-7609058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-7690156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-7724576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-7865481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-8009221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-8057437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-8456300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-8456301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-8585759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-8760813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-8864138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-8871654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-9222384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-9294203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-9400592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-9525595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-9746071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-9815213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10864685-9971753
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6680-3
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10864685-Acute Disease,
pubmed-meshheading:10864685-Animals,
pubmed-meshheading:10864685-Cercopithecus aethiops,
pubmed-meshheading:10864685-DNA, Viral,
pubmed-meshheading:10864685-Disease Models, Animal,
pubmed-meshheading:10864685-Eye Infections, Viral,
pubmed-meshheading:10864685-Herpesvirus 1, Human,
pubmed-meshheading:10864685-Interferon-gamma,
pubmed-meshheading:10864685-Mice,
pubmed-meshheading:10864685-Mice, Inbred BALB C,
pubmed-meshheading:10864685-Mice, Inbred C57BL,
pubmed-meshheading:10864685-Mice, Knockout,
pubmed-meshheading:10864685-Polymerase Chain Reaction,
pubmed-meshheading:10864685-Species Specificity,
pubmed-meshheading:10864685-Trigeminal Ganglion,
pubmed-meshheading:10864685-Ultraviolet Rays,
pubmed-meshheading:10864685-Vero Cells,
pubmed-meshheading:10864685-Virus Activation,
pubmed-meshheading:10864685-Virus Latency
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pubmed:year |
2000
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pubmed:articleTitle |
Gamma interferon impedes the establishment of herpes simplex virus type 1 latent infection but has no impact on its maintenance or reactivation in mice.
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pubmed:affiliation |
Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
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pubmed:publicationType |
Journal Article
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