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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2000-7-12
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pubmed:abstractText |
The involvement of serotonin in depression and suicide has been proposed, because major depression is successfully treated by medications that specifically block the serotonin transporter, and there is evidence for a decrease in serotonin transporters in major depression and suicide. The midbrain dorsal raphe nucleus (DR) has been implicated as a site for diminished serotonergic activity in that suicide victims with major depression have a significant increase in serotonin-1A autoreceptors in the DR.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-3223
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1015-24
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10862800-Adult,
pubmed-meshheading:10862800-Aged,
pubmed-meshheading:10862800-Aged, 80 and over,
pubmed-meshheading:10862800-Autoradiography,
pubmed-meshheading:10862800-Carrier Proteins,
pubmed-meshheading:10862800-Depressive Disorder,
pubmed-meshheading:10862800-Female,
pubmed-meshheading:10862800-Humans,
pubmed-meshheading:10862800-Immunohistochemistry,
pubmed-meshheading:10862800-Male,
pubmed-meshheading:10862800-Membrane Glycoproteins,
pubmed-meshheading:10862800-Membrane Transport Proteins,
pubmed-meshheading:10862800-Mesencephalon,
pubmed-meshheading:10862800-Middle Aged,
pubmed-meshheading:10862800-Nerve Tissue Proteins,
pubmed-meshheading:10862800-Paroxetine,
pubmed-meshheading:10862800-Radioligand Assay,
pubmed-meshheading:10862800-Retrospective Studies,
pubmed-meshheading:10862800-Serotonin,
pubmed-meshheading:10862800-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:10862800-Serotonin Uptake Inhibitors,
pubmed-meshheading:10862800-Suicide
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pubmed:year |
2000
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pubmed:articleTitle |
The serotonin transporter in the midbrain of suicide victims with major depression.
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pubmed:affiliation |
Department of Pathology, University Hospitals of Cleveland, Case Western Reserve University, OH, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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