Linked Life Data

10861450

Source:http://linkedlifedata.com/resource/pubmed/id/10861450

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10861450rdf:typepubmed:Citationlld:pubmed
pubmed-article:10861450lifeskim:mentionsumls-concept:C0007600lld:lifeskim
pubmed-article:10861450lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:10861450lifeskim:mentionsumls-concept:C0376358lld:lifeskim
pubmed-article:10861450lifeskim:mentionsumls-concept:C0035647lld:lifeskim
pubmed-article:10861450lifeskim:mentionsumls-concept:C0334227lld:lifeskim
pubmed-article:10861450lifeskim:mentionsumls-concept:C0003691lld:lifeskim
pubmed-article:10861450lifeskim:mentionsumls-concept:C1522484lld:lifeskim
pubmed-article:10861450lifeskim:mentionsumls-concept:C0542341lld:lifeskim
pubmed-article:10861450lifeskim:mentionsumls-concept:C0036525lld:lifeskim
pubmed-article:10861450lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:10861450lifeskim:mentionsumls-concept:C0475264lld:lifeskim
pubmed-article:10861450lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:10861450lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:10861450pubmed:issue1lld:pubmed
pubmed-article:10861450pubmed:dateCreated2000-7-13lld:pubmed
pubmed-article:10861450pubmed:abstractTextThe involvement of 12-lipoxygenase (12-LOX) expression and function in tumor metastasis has been demonstrated in several murine tumor cell lines. In addition, 12-LOX expression was detected in human prostatic tumors and correlated to the clinical stage of disease. Here we provide data that human prostate cancer cell lines express the platelet-type isoform of 12-LOX at both the mRNA and protein levels, and immunohistochemistry revealed 12-LOX expression in human prostate tumors. The enzyme was localized to the plasma membrane, cytoplasmic organelles and nucleus in non-metastatic cells (PC-3 nm) and to the cytoskeleton and nucleus in metastatic cells (DU-145). After orthotopic/intraprostatic injection of tumor cells into SCID mice, the metastatic prostate carcinoma cells (DU-145) expressed 12-LOX at a significantly higher level compared with the non-metastatic counterparts, PC-3nm. The functional involvement of 12-LOX in the metastatic process was demonstrated when DU-145 cells were pretreated in vitro with the 12-LOX inhibitors N-benzyl-N-hydroxy-5-phenylpentamide (BHPP) or baicalein, the use of which significantly inhibited lung colonization. These data suggest a potential involvement of 12-LOX in the progression of human prostate cancer.lld:pubmed
pubmed-article:10861450pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10861450pubmed:languageenglld:pubmed
pubmed-article:10861450pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10861450pubmed:citationSubsetIMlld:pubmed
pubmed-article:10861450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10861450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10861450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10861450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10861450pubmed:statusMEDLINElld:pubmed
pubmed-article:10861450pubmed:monthJullld:pubmed
pubmed-article:10861450pubmed:issn0020-7136lld:pubmed
pubmed-article:10861450pubmed:authorpubmed-author:LORRlld:pubmed
pubmed-article:10861450pubmed:authorpubmed-author:HagmannWWlld:pubmed
pubmed-article:10861450pubmed:authorpubmed-author:HonnK VKVlld:pubmed
pubmed-article:10861450pubmed:authorpubmed-author:OKAKKlld:pubmed
pubmed-article:10861450pubmed:authorpubmed-author:TimárJJlld:pubmed
pubmed-article:10861450pubmed:authorpubmed-author:GrignonDDlld:pubmed
pubmed-article:10861450pubmed:authorpubmed-author:DölzHHlld:pubmed
pubmed-article:10861450pubmed:authorpubmed-author:RásóEElld:pubmed
pubmed-article:10861450pubmed:copyrightInfoCopyright 2000 Wiley-Liss, Inc.lld:pubmed
pubmed-article:10861450pubmed:issnTypePrintlld:pubmed
pubmed-article:10861450pubmed:day1lld:pubmed
pubmed-article:10861450pubmed:volume87lld:pubmed
pubmed-article:10861450pubmed:ownerNLMlld:pubmed
pubmed-article:10861450pubmed:authorsCompleteYlld:pubmed
pubmed-article:10861450pubmed:pagination37-43lld:pubmed
pubmed-article:10861450pubmed:dateRevised2010-11-18lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:meshHeadingpubmed-meshheading:10861450...lld:pubmed
pubmed-article:10861450pubmed:year2000lld:pubmed
pubmed-article:10861450pubmed:articleTitleExpression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential.lld:pubmed
pubmed-article:10861450pubmed:affiliationDepartment of Tumor Progression, National Institute of Oncology, Budapest, Hungary. jtimar@oncol.hulld:pubmed
pubmed-article:10861450pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10861450pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:10861450pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10861450lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10861450lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10861450lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10861450lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10861450lld:pubmed