| pubmed-article:10861313 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10861313 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:10861313 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:10861313 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:10861313 | lifeskim:mentions | umls-concept:C0525037 | lld:lifeskim |
| pubmed-article:10861313 | lifeskim:mentions | umls-concept:C0694873 | lld:lifeskim |
| pubmed-article:10861313 | lifeskim:mentions | umls-concept:C0041703 | lld:lifeskim |
| pubmed-article:10861313 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10861313 | pubmed:dateCreated | 2000-7-25 | lld:pubmed |
| pubmed-article:10861313 | pubmed:abstractText | Two genes have been implicated in the development of cutaneous malignant melanoma (CMM). CDK4 (the gene encoding cyclin-dependent kinase 4, an oncogene) has exhibited germline mutations found in only three melanoma-prone families to date. CDKN2A is a tumor suppressor gene that encodes p16 (which inhibits activity of the cyclin D1-CDK4 complex) with germline mutations detected in 10%-25% of melanoma-prone families, some of whom are also prone to pancreatic cancer. | lld:pubmed |
| pubmed-article:10861313 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10861313 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10861313 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10861313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10861313 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10861313 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10861313 | pubmed:issn | 0027-8874 | lld:pubmed |
| pubmed-article:10861313 | pubmed:author | pubmed-author:GoldsteinA... | lld:pubmed |
| pubmed-article:10861313 | pubmed:author | pubmed-author:TuckerM AMA | lld:pubmed |
| pubmed-article:10861313 | pubmed:author | pubmed-author:ChidambaramAA | lld:pubmed |
| pubmed-article:10861313 | pubmed:author | pubmed-author:StruewingJ... | lld:pubmed |
| pubmed-article:10861313 | pubmed:author | pubmed-author:FraserM CMC | lld:pubmed |
| pubmed-article:10861313 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10861313 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:10861313 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:10861313 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10861313 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10861313 | pubmed:pagination | 1006-10 | lld:pubmed |
| pubmed-article:10861313 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10861313 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10861313 | pubmed:articleTitle | Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations. | lld:pubmed |
| pubmed-article:10861313 | pubmed:affiliation | Genetic Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-7236, USA. goldstea@exchange.nih.gov | lld:pubmed |
| pubmed-article:10861313 | pubmed:publicationType | Journal Article | lld:pubmed |
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