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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2000-7-25
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pubmed:abstractText |
Two genes have been implicated in the development of cutaneous malignant melanoma (CMM). CDK4 (the gene encoding cyclin-dependent kinase 4, an oncogene) has exhibited germline mutations found in only three melanoma-prone families to date. CDKN2A is a tumor suppressor gene that encodes p16 (which inhibits activity of the cyclin D1-CDK4 complex) with germline mutations detected in 10%-25% of melanoma-prone families, some of whom are also prone to pancreatic cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1006-10
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10861313-Adolescent,
pubmed-meshheading:10861313-Adult,
pubmed-meshheading:10861313-Age Factors,
pubmed-meshheading:10861313-Aged,
pubmed-meshheading:10861313-Arginine,
pubmed-meshheading:10861313-Aspartic Acid,
pubmed-meshheading:10861313-Cyclin-Dependent Kinases,
pubmed-meshheading:10861313-Cysteine,
pubmed-meshheading:10861313-Genes, p16,
pubmed-meshheading:10861313-Genotype,
pubmed-meshheading:10861313-Germ-Line Mutation,
pubmed-meshheading:10861313-Glycine,
pubmed-meshheading:10861313-Haplotypes,
pubmed-meshheading:10861313-Humans,
pubmed-meshheading:10861313-Melanoma,
pubmed-meshheading:10861313-Middle Aged,
pubmed-meshheading:10861313-Nevus,
pubmed-meshheading:10861313-Pancreatic Neoplasms,
pubmed-meshheading:10861313-Phenotype,
pubmed-meshheading:10861313-Skin Neoplasms,
pubmed-meshheading:10861313-Statistics, Nonparametric,
pubmed-meshheading:10861313-Tryptophan,
pubmed-meshheading:10861313-United States,
pubmed-meshheading:10861313-Valine
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pubmed:year |
2000
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pubmed:articleTitle |
Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations.
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pubmed:affiliation |
Genetic Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-7236, USA. goldstea@exchange.nih.gov
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pubmed:publicationType |
Journal Article
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