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rdf:type |
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lifeskim:mentions |
umls-concept:C0001047,
umls-concept:C0006826,
umls-concept:C0008976,
umls-concept:C0029246,
umls-concept:C0030705,
umls-concept:C0034656,
umls-concept:C0035168,
umls-concept:C0042839,
umls-concept:C0087111,
umls-concept:C0239307,
umls-concept:C0278996,
umls-concept:C0460004,
umls-concept:C0684249,
umls-concept:C1521808
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pubmed:issue |
12
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pubmed:dateCreated |
2000-7-25
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|
pubmed:abstractText |
Preclinical evidence suggests that retinoids and antioxidants may prevent or delay the occurrence of cancer in the upper or lower airways, but such effects have not been reliably established in clinical studies. To assess the chemopreventive effects of vitamin A (retinyl palmitate) and N-acetylcysteine, we conducted a large randomized intervention study in patients with head and neck cancer or with lung cancer, most of whom had a history of smoking.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
977-86
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10861309-Acetylcysteine,
pubmed-meshheading:10861309-Adult,
pubmed-meshheading:10861309-Aged,
pubmed-meshheading:10861309-Aged, 80 and over,
pubmed-meshheading:10861309-Anticarcinogenic Agents,
pubmed-meshheading:10861309-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:10861309-Disease-Free Survival,
pubmed-meshheading:10861309-Drug Administration Schedule,
pubmed-meshheading:10861309-Europe,
pubmed-meshheading:10861309-Female,
pubmed-meshheading:10861309-Head and Neck Neoplasms,
pubmed-meshheading:10861309-Humans,
pubmed-meshheading:10861309-Lung Neoplasms,
pubmed-meshheading:10861309-Male,
pubmed-meshheading:10861309-Middle Aged,
pubmed-meshheading:10861309-Neoplasms, Second Primary,
pubmed-meshheading:10861309-Patient Compliance,
pubmed-meshheading:10861309-Risk Factors,
pubmed-meshheading:10861309-Smoking,
pubmed-meshheading:10861309-Survival Analysis,
pubmed-meshheading:10861309-Treatment Failure,
pubmed-meshheading:10861309-Vitamin A
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pubmed:year |
2000
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pubmed:articleTitle |
EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups.
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pubmed:affiliation |
The Netherlands Cancer Institute, Amsterdam. zandwijk@nki.nl
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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