Source:http://linkedlifedata.com/resource/pubmed/id/10858983
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2000-9-21
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| pubmed:abstractText |
Bronchial eosinophilic inflammation and bronchial hyperresponsiveness (BHR) are the main features of allergic asthma (AA), but they have also been demonstrated in allergic rhinitis (AR), suggesting a continuity between both diseases. In spite of not fully reproducing natural allergenic exposure, the allergen bronchial provocation test (A-BPT) has provided important knowledge of the pathophysiology of AA. Our aim was to verify the existence of a behavior of AA and AR airways different from the allergen bronchial challenge-induced airway eosinophilic inflammation and BHR changes. We studied a group of 31 mild and short-evolution AA and 15 AR patients, sensitized to Dermatophagoides pteronyssinus. The A-BPT was performed with a partially biologically standardized D. pteronyssinus extract, and known quantities of Der p 1 were inhaled. Peripheral blood (eosinophils and ECP) and induced sputum (percentage cell counts, ECP, albumin, tryptase, and interleukin [IL]-5) were analyzed, before and 24 h after A-BPT. Methacholine BHR, assessed before and 32 h after the A-BPT, was defined by M-PD20 values and, when possible, by maximal response plateau (MRP). The A-BPT was well tolerated by all the patients. AA presented a lower Der p 1 PD20 and a higher occurrence of late-phase responses (LPR). M-PD20 values decreased in AA, but not in AR, patients. MRP values increased in both groups. Eosinophils numbers and ECP levels increased in blood and sputum from both AA and AR, but only the absolute increment of sputum ECP levels was higher in AA than AR patients (P = 0.025). The A-BPT induced no change in sputum albumin, tryptase, or IL-5 values. We conclude as follows: 1) In spite of presenting a lower degree of bronchial sensitivity to allergen, AR patients responded to allergen inhalation with an eosinophilic inflammation enhancement very similar to that observed among AA. 2) MRP levels increased in both AA and AR patients after allergen challenge; however, M-PD20 values significantly changed only in the AA group, suggesting that the components of the airway response to methacholine were controlled by different mechanisms. 3) It is possible that the differences between AR and AA lie only in the quantitative bronchial response to allergen inhalation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Dermatophagoides,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Chymases,
http://linkedlifedata.com/resource/pubmed/chemical/Eosinophil Granule Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/Methacholine Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptases,
http://linkedlifedata.com/resource/pubmed/chemical/chymase 2
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0105-4538
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
55
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
531-9
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10858983-Adult,
pubmed-meshheading:10858983-Antigens, Dermatophagoides,
pubmed-meshheading:10858983-Asthma,
pubmed-meshheading:10858983-Blood Proteins,
pubmed-meshheading:10858983-Bronchial Hyperreactivity,
pubmed-meshheading:10858983-Bronchial Provocation Tests,
pubmed-meshheading:10858983-Cell Count,
pubmed-meshheading:10858983-Chymases,
pubmed-meshheading:10858983-Eosinophil Granule Proteins,
pubmed-meshheading:10858983-Eosinophils,
pubmed-meshheading:10858983-Female,
pubmed-meshheading:10858983-Forced Expiratory Volume,
pubmed-meshheading:10858983-Glycoproteins,
pubmed-meshheading:10858983-Humans,
pubmed-meshheading:10858983-Interleukin-5,
pubmed-meshheading:10858983-Male,
pubmed-meshheading:10858983-Methacholine Chloride,
pubmed-meshheading:10858983-Pulmonary Eosinophilia,
pubmed-meshheading:10858983-Rhinitis, Allergic, Perennial,
pubmed-meshheading:10858983-Ribonucleases,
pubmed-meshheading:10858983-Serine Endopeptidases,
pubmed-meshheading:10858983-Serum Albumin,
pubmed-meshheading:10858983-Sputum,
pubmed-meshheading:10858983-Tryptases
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| pubmed:year |
2000
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| pubmed:articleTitle |
Comparison of allergen-induced changes in bronchial hyperresponsiveness and airway inflammation between mildly allergic asthma patients and allergic rhinitis patients.
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| pubmed:affiliation |
Servicio de Alergología, Hospital de León, Spain.
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
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