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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-11-9
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pubmed:abstractText |
The photooxidation of calf-thymus DNA has been investigated in the presence of a supramolecular tetraruthenated zincporphyrin (ZnTRP) sensitizer. A strong interaction of ZnTRP with DNA has been observed, exhibiting a gradual transition from a non-specific electrostatic binding mode to a more specific one at high DNA concentrations. Formation of O2(1delta(g)) has been detected from its near-infrared emission, after the excitation of ZnTRP in dioxygen-containing solutions. In the presence of DNA and dioxygen, ZnTRP promotes efficient photocatalytic oxidation of the 2'-deoxyguanosine sites, via their direct reaction with O2(1delta(g)), as in a previous work on the ZnTRP-photoinduced oxidation of the free nucleosides.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0162-0134
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10857906-Animals,
pubmed-meshheading:10857906-Cattle,
pubmed-meshheading:10857906-Chromatography, High Pressure Liquid,
pubmed-meshheading:10857906-DNA,
pubmed-meshheading:10857906-Dose-Response Relationship, Drug,
pubmed-meshheading:10857906-Kinetics,
pubmed-meshheading:10857906-Light,
pubmed-meshheading:10857906-Models, Chemical,
pubmed-meshheading:10857906-Organometallic Compounds,
pubmed-meshheading:10857906-Oxygen,
pubmed-meshheading:10857906-Porphyrins,
pubmed-meshheading:10857906-Protein Binding,
pubmed-meshheading:10857906-Spectrometry, Fluorescence,
pubmed-meshheading:10857906-Thymus Gland,
pubmed-meshheading:10857906-Time Factors,
pubmed-meshheading:10857906-Zinc
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pubmed:year |
2000
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pubmed:articleTitle |
Zinc tetraruthenated porphyrin binding and photoinduced oxidation of calf-thymus DNA.
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pubmed:affiliation |
Instituto de Química, Universidade de São Paulo, SP, Brazil. koiaraki@iq.usp.br
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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