|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2000-6-30
|
|
pubmed:abstractText |
Peripheral blood (PB) T cells from rheumatoid arthritis (RA) patients proliferate poorly to mitogen, a change that is related to decreased intracellular Ca2+ ([Ca2+]i) signaling after T cell receptor (TCR) stimulation. We hypothesized that this was, in part, due to the effect of mediators of inflammation and predicted that greater changes in [Ca2+]i signaling would be seen in synovial fluid (SF) T cells. We also examined the mechanisms underlying the altered [Ca2+]i signals.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0004-3591
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
43
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1257-65
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10857784-Arthritis, Rheumatoid,
pubmed-meshheading:10857784-Calcium,
pubmed-meshheading:10857784-Calcium Signaling,
pubmed-meshheading:10857784-Chronic Disease,
pubmed-meshheading:10857784-Endoplasmic Reticulum,
pubmed-meshheading:10857784-Enzyme Inhibitors,
pubmed-meshheading:10857784-Humans,
pubmed-meshheading:10857784-Inositol 1,4,5-Trisphosphate,
pubmed-meshheading:10857784-Intracellular Membranes,
pubmed-meshheading:10857784-Ionomycin,
pubmed-meshheading:10857784-Ionophores,
pubmed-meshheading:10857784-Organelles,
pubmed-meshheading:10857784-Reference Values,
pubmed-meshheading:10857784-Synovial Fluid,
pubmed-meshheading:10857784-T-Lymphocytes,
pubmed-meshheading:10857784-Thapsigargin
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Dysregulated intracellular Ca2+ stores and Ca2+ signaling in synovial fluid T lymphocytes from patients with chronic inflammatory arthritis.
|
|
pubmed:affiliation |
Department of Rheumatology, University of Birmingham, UK.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
