| pubmed-article:10854750 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10854750 | lifeskim:mentions | umls-concept:C0037925 | lld:lifeskim |
| pubmed-article:10854750 | lifeskim:mentions | umls-concept:C0079883 | lld:lifeskim |
| pubmed-article:10854750 | lifeskim:mentions | umls-concept:C0751214 | lld:lifeskim |
| pubmed-article:10854750 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10854750 | lifeskim:mentions | umls-concept:C0900627 | lld:lifeskim |
| pubmed-article:10854750 | lifeskim:mentions | umls-concept:C1333226 | lld:lifeskim |
| pubmed-article:10854750 | lifeskim:mentions | umls-concept:C1705335 | lld:lifeskim |
| pubmed-article:10854750 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:10854750 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10854750 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10854750 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10854750 | pubmed:dateCreated | 2000-8-18 | lld:pubmed |
| pubmed-article:10854750 | pubmed:abstractText | PSD-95/SAP90, a molecular scaffold protein, attaches the N-methyl-D-aspartate receptor to cellular signaling pathways through PSD-95/DLG/Z0-1 domain interactions at neuronal synapses.(5,9) This suggests that PSD-95/SAP90 might be involved in many physiological and pathophysiological actions triggered via the N-methyl-D-aspartate receptor in the central nervous system. Here, we present evidence that suppression of the expression of PSD-95/SAP90 in the spinal cord significantly attenuated facilitation of the tail-flick reflex triggered through N-methyl-D-aspartate receptor activation but not baseline tail-flick reflex latency. Moreover, PSD-95/SAP90's messenger RNA and protein were enriched in the spinal cord and selectively distributed in the superficial dorsal horn, where PSD-95/SAP90 overlapped with the N-methyl-D-aspartate receptor. In spinal cord neurons, PSD-95/SAP90 interacted with the N-methyl-D-aspartate receptor subunits 2A/2B. It is indicated that activation of the N-methyl-D-aspartate receptor in spinal hyperalgesia results in association of the N-methyl-D-aspartate receptor with PSD-95/SAP90 and that PSD-95/SAP90 is required for noxious thermal hyperalgesia triggered via the N-methyl-D-aspartate receptor at the spinal cord level. The present findings may provide novel insights into the mechanisms for persistent sensitization of the somatosensory system. | lld:pubmed |
| pubmed-article:10854750 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10854750 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10854750 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10854750 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10854750 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10854750 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10854750 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10854750 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10854750 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10854750 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10854750 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10854750 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10854750 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10854750 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:10854750 | pubmed:author | pubmed-author:HuangY ZYZ | lld:pubmed |
| pubmed-article:10854750 | pubmed:author | pubmed-author:TaoY XYX | lld:pubmed |
| pubmed-article:10854750 | pubmed:author | pubmed-author:JohnsR ARA | lld:pubmed |
| pubmed-article:10854750 | pubmed:author | pubmed-author:MeiLL | lld:pubmed |
| pubmed-article:10854750 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10854750 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:10854750 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10854750 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10854750 | pubmed:pagination | 201-6 | lld:pubmed |
| pubmed-article:10854750 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10854750 | pubmed:meshHeading | pubmed-meshheading:10854750... | lld:pubmed |
| pubmed-article:10854750 | pubmed:meshHeading | pubmed-meshheading:10854750... | lld:pubmed |
| pubmed-article:10854750 | pubmed:meshHeading | pubmed-meshheading:10854750... | lld:pubmed |
| pubmed-article:10854750 | pubmed:meshHeading | pubmed-meshheading:10854750... | lld:pubmed |
| pubmed-article:10854750 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10854750 | pubmed:articleTitle | Expression of PSD-95/SAP90 is critical for N-methyl-D-aspartate receptor-mediated thermal hyperalgesia in the spinal cord. | lld:pubmed |
| pubmed-article:10854750 | pubmed:affiliation | Department of Anesthesiology and Critical Care Medicine, Blalock 1415, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287-4965, USA. | lld:pubmed |
| pubmed-article:10854750 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10854750 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10854750 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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