Source:http://linkedlifedata.com/resource/pubmed/id/10854726
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2000-8-17
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pubmed:abstractText |
Striatal glutamate release during novelty exposure-induced hyperactivity was studied by microdialysis in freely-moving olfactory bulbectomized (OBX) rats. After collecting three 10 min basal striatal dialysate samples, the animals were transferred to an open-field apparatus (novelty) and locomotor activity recorded for 60 min. OBX rats showed significantly more locomotor activity (1210+/-270 cm) than sham-operated rats (420+/-70 cm), but only in the first 10 min after exposure to the novel environment. During the same period, striatal glutamate levels increased to 163+/-21% of the basal value in OBX rats, while no changes were seen in the striatum of sham-operated controls. These findings suggest that olfactory bulbectomy results in an increased response of the striatal glutamatergic system to novelty stress, and may consequently cause hyperactivity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
287
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
117-20
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10854726-Animals,
pubmed-meshheading:10854726-Behavior, Animal,
pubmed-meshheading:10854726-Corpus Striatum,
pubmed-meshheading:10854726-Denervation,
pubmed-meshheading:10854726-Exploratory Behavior,
pubmed-meshheading:10854726-Glutamic Acid,
pubmed-meshheading:10854726-Locomotion,
pubmed-meshheading:10854726-Male,
pubmed-meshheading:10854726-Microdialysis,
pubmed-meshheading:10854726-Olfactory Bulb,
pubmed-meshheading:10854726-Psychomotor Agitation,
pubmed-meshheading:10854726-Rats,
pubmed-meshheading:10854726-Rats, Wistar,
pubmed-meshheading:10854726-Stress, Physiological
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pubmed:year |
2000
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pubmed:articleTitle |
Striatal glutamate release during novelty exposure-induced hyperactivity in olfactory bulbectomized rats.
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pubmed:affiliation |
Department of Physiology, College of Medicine, National Taiwan University, Taipei, Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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