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rdf:type |
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lifeskim:mentions |
umls-concept:C0031727,
umls-concept:C0086982,
umls-concept:C0205263,
umls-concept:C0851827,
umls-concept:C1150587,
umls-concept:C1160520,
umls-concept:C1367731,
umls-concept:C1701901,
umls-concept:C1704259,
umls-concept:C1705632,
umls-concept:C1705987
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pubmed:issue |
6
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pubmed:dateCreated |
2000-6-27
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pubmed:abstractText |
We have previously found that microinjection of activated MEK (mitogen activated kinase kinase) and ERK (mitogen-activated protein; MAP kinase) fails to induce oocyte maturation, but that maturation, induced by oncogenic ras-p21 and insulin-activated cell ras-p21, is blocked by peptides from the ras-binding domain of raf. We also found that jun kinase (JNK), on the stress-activated protein (SAP) pathway, which is critical to the oncogenic ras-p21 signal transduction pathway, is a strong inducer of oocyte maturation. Our purpose in this study was to determine the role of the raf-MEK-MAP kinase pathway in oocyte maturation and how it interacts with JNK from the SAP pathway.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0344-5704
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pubmed:author |
pubmed-author:AdlerVV,
pubmed-author:AmaoTT,
pubmed-author:Brandt-RaufP WPW,
pubmed-author:ChenHH,
pubmed-author:ChinGG,
pubmed-author:ChungD LDL,
pubmed-author:FriedmanF KFK,
pubmed-author:KovalJJ,
pubmed-author:LinM CMC,
pubmed-author:MARSP HPH,
pubmed-author:MichlJJ,
pubmed-author:PincusM RMR,
pubmed-author:RobinsonR CRC,
pubmed-author:RonaiZZ,
pubmed-author:YamaizumiZZ
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
441-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10854130-Animals,
pubmed-meshheading:10854130-Female,
pubmed-meshheading:10854130-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:10854130-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10854130-Models, Biological,
pubmed-meshheading:10854130-Oocytes,
pubmed-meshheading:10854130-Protein-Serine-Threonine Kinases,
pubmed-meshheading:10854130-Proto-Oncogene Proteins c-raf,
pubmed-meshheading:10854130-Proto-Oncogene Proteins p21(ras),
pubmed-meshheading:10854130-Signal Transduction,
pubmed-meshheading:10854130-Xenopus laevis
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pubmed:year |
2000
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pubmed:articleTitle |
Induction of oocyte maturation by jun-N-terminal kinase (JNK) on the oncogenic ras-p21 pathway is dependent on the raf-MEK signal transduction pathway.
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pubmed:affiliation |
Department of Biology, Long Island University, Brooklyn, NY 11201, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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