Source:http://linkedlifedata.com/resource/pubmed/id/10854034
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2000-10-17
|
| pubmed:abstractText |
We have investigated the potential role of neurotrophic factors in antipsychotic drug action by examining the effects of antipsychotic and psychotropic treatments on the mRNA expression of brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and their receptors, trkB and trkC, respectively, in rat brain. Neither acute nor chronic clozapine treatment significantly affected the expression of these mRNAs in any brain area investigated, except for a decrease in trkB expression in the granule cells of the olfactory bulb. We then examined the effects of the psychotropic agent MK-801. MK-801 (5 mg/kg; 4 h) significantly increased BDNF mRNA in the entorhinal cortex, but did not influence NT-3, trkB, or trkC expression in any brain area except for the olfactory bulb. The induction of BDNF mRNA by MK-801 was attenuated by pre-treatment (1 h prior to MK-801 administration) with the antipsychotics, clozapine (25 mg/kg) and haloperidol (2 mg/kg), but not with the antidepressant desipramine (15 mg/kg). Finally, we confirmed that the effects of MK-801 on BDNF mRNA were reflected in the respective changes in BDNF protein levels: MK-801 significantly increased anti-BDNF reactivity in the entorhinal cortex (126 +/- 7% of control) while concomitantly decreasing in the hippocampus (71 +/- 2% of control). These data do not support the hypothesis that neurotrophins play an important role in antipsychotic drug action, but rather suggest that induction of BDNF in the entorhinal cortex may play a significant role in the psychotropic action of MK-801.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antipsychotic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Brain-Derived Neurotrophic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Clozapine,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotrophin 3,
http://linkedlifedata.com/resource/pubmed/chemical/Psychotropic Drugs,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, trkB,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, trkC
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0895-8696
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
27-37
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:10854034-Animals,
pubmed-meshheading:10854034-Antipsychotic Agents,
pubmed-meshheading:10854034-Brain,
pubmed-meshheading:10854034-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:10854034-Clozapine,
pubmed-meshheading:10854034-Dizocilpine Maleate,
pubmed-meshheading:10854034-Entorhinal Cortex,
pubmed-meshheading:10854034-Gene Expression Regulation,
pubmed-meshheading:10854034-Hippocampus,
pubmed-meshheading:10854034-Male,
pubmed-meshheading:10854034-Neurotrophin 3,
pubmed-meshheading:10854034-Psychotropic Drugs,
pubmed-meshheading:10854034-RNA, Messenger,
pubmed-meshheading:10854034-Rats,
pubmed-meshheading:10854034-Rats, Wistar,
pubmed-meshheading:10854034-Receptor, trkB,
pubmed-meshheading:10854034-Receptor, trkC,
pubmed-meshheading:10854034-Transcription, Genetic
|
| pubmed:articleTitle |
Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents.
|
| pubmed:affiliation |
A. I. Virtanen Institute, University of Kuopio, Finland.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|