Source:http://linkedlifedata.com/resource/pubmed/id/10853708
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2000-9-15
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| pubmed:abstractText |
Activin A is a dimeric glycoprotein showing a high sequence homology with transforming growth factor-beta (TGF-beta) and playing autocrine/paracrine actions in reproductive tissues. However, since the synthesis of activin is ubiquitous it may have a role in regulating cell growth and differentiation in several tissues. Previous studies showed that activin A is expressed by insulin-positive B cells of human pancreatic islets, and women with gestational diabetes have higher serum activin A levels than healthy pregnant women at the same gestational age. The present study aimed to evaluate the effect of activin A on insulin secretion from cultured human pancreatic islets. With this purpose human pancreatic islets were incubated with varying concentrations of activin A (0.1 to 10.0 nM). In absence of glucose, activin A did not modify insulin secretion at the different concentrations used. In absence of activin A, 8.3 mM and 16.7 mM glucose significantly increased insulin secretion, with a dose-dependent pattern. In presence of a non stimulatory concentration of glucose (3.3 mM), activin A significantly increased insulin secretion starting from low concentration (0.1 nM). Furthermore, the addition of activin A to 8.3 mM and 16.7 mM glucose induced an additional effect of the dose-dependent glucose-mediated insulin secretion (p<0.001). The present data could support a role for activin A in human endocrine pancreas in modulating insulin response to different glucose concentrations.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
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| pubmed:issn |
0391-4097
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
23
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
231-4
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10853708-Activins,
pubmed-meshheading:10853708-Culture Techniques,
pubmed-meshheading:10853708-Dose-Response Relationship, Drug,
pubmed-meshheading:10853708-Glucose,
pubmed-meshheading:10853708-Humans,
pubmed-meshheading:10853708-Inhibins,
pubmed-meshheading:10853708-Insulin,
pubmed-meshheading:10853708-Islets of Langerhans
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Activin A stimulates insulin secretion in cultured human pancreatic islets.
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| pubmed:affiliation |
Department of Reproductive Medicine and Child Development, Section of Obstetrics and Gynecology, University of Pisa, Italy.
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| pubmed:publicationType |
Journal Article
|